The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin: Implications for Antiangiogenic Strategies

The plasminogen (Plg)/plasminogen activator (PA) system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumor cell migration. Consequently, urokinase-type PA (uPA)/plasmin antagonists are currently being developed for suppression of tumor growth...

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Detalles Bibliográficos
Autores principales: Bajou, Khalid, Masson, Véronique, Gerard, Robert D., Schmitt, Petra M., Albert, Valérie, Praus, Michael, Lund, Leif R., Frandsen, Thomas L., Brunner, Nils, Dano, Keld, Fusenig, Norbert E., Weidle, Ulrich, Carmeliet, Geert, Loskutoff, David, Collen, Desiré, Carmeliet, Peter, Foidart, Jean Michel, Noël, Agnès
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195770/
https://www.ncbi.nlm.nih.gov/pubmed/11266468

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