Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes

Rab27a activity is affected in several mouse models of human disease including Griscelli (ashen mice) and Hermansky-Pudlak (gunmetal mice) syndromes. A loss of function mutation occurs in the Rab27a gene in ashen (ash), whereas in gunmetal (gm) Rab27a dysfunction is secondary to a mutation in the α...

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Detalles Bibliográficos
Autores principales: Stinchcombe, Jane C., Barral, Duarte C., Mules, Emilie H., Booth, Sarah, Hume, Alistair N., Machesky, Laura M., Seabra, Miguel C., Griffiths, Gillian M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195783/
https://www.ncbi.nlm.nih.gov/pubmed/11266472

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