Mapping the Energy of Superantigen Staphylococcus Enterotoxin C3 Recognition of an α/β T Cell Receptor Using Alanine Scanning Mutagenesis

Binding of the T cell receptor (TCR) to a bacterial superantigen (SAG) results in stimulation of a large population of T cells and subsequent inflammatory reactions. To define the functional contribution of TCR residues to SAG recognition, binding by 24 single-site alanine substitutions in the TCR V...

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Detalles Bibliográficos
Autores principales: Churchill, Hywyn R.O., Andersen, Peter S., Parke, Evan A., Mariuzza, Roy A., Kranz, David M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195847/
https://www.ncbi.nlm.nih.gov/pubmed/10704464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195847/
https://www.ncbi.nlm.nih.gov/pubmed/10704464

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