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Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis
In addition to their well characterized role in allergic inflammation, recent data confirm that mast cells play a more extensive role in a variety of immune responses. However, their contribution to autoimmune and neurologic disease processes has not been investigated. Experimental allergic encephal...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195850/ https://www.ncbi.nlm.nih.gov/pubmed/10704463 |
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author | Secor, Virginia H. Secor, W. Evan Gutekunst, Claire-Anne Brown, Melissa A. |
author_facet | Secor, Virginia H. Secor, W. Evan Gutekunst, Claire-Anne Brown, Melissa A. |
author_sort | Secor, Virginia H. |
collection | PubMed |
description | In addition to their well characterized role in allergic inflammation, recent data confirm that mast cells play a more extensive role in a variety of immune responses. However, their contribution to autoimmune and neurologic disease processes has not been investigated. Experimental allergic encephalomyelitis (EAE) and its human disease counterpart, multiple sclerosis, are considered to be CD4(+) T cell–mediated autoimmune diseases affecting the central nervous system. Several lines of indirect evidence suggest that mast cells could also play a role in the pathogenesis of both the human and murine disease. Using a myelin oligodendrocyte glycoprotein (MOG)-induced model of acute EAE, we show that mast cell–deficient W/W(v) mice exhibit significantly reduced disease incidence, delayed disease onset, and decreased mean clinical scores when compared with their wild-type congenic littermates. No differences were observed in MOG-specific T and B cell responses between the two groups, indicating that a global T or B cell defect is not present in W/W(v) animals. Reconstitution of the mast cell population in W/W(v) mice restores induction of early and severe disease to wild-type levels, suggesting that mast cells are critical for the full manifestation of disease. These data provide a new mechanism for immune destruction in EAE and indicate that mast cells play a broader role in neurologic inflammation. |
format | Text |
id | pubmed-2195850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21958502008-04-16 Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis Secor, Virginia H. Secor, W. Evan Gutekunst, Claire-Anne Brown, Melissa A. J Exp Med Original Article In addition to their well characterized role in allergic inflammation, recent data confirm that mast cells play a more extensive role in a variety of immune responses. However, their contribution to autoimmune and neurologic disease processes has not been investigated. Experimental allergic encephalomyelitis (EAE) and its human disease counterpart, multiple sclerosis, are considered to be CD4(+) T cell–mediated autoimmune diseases affecting the central nervous system. Several lines of indirect evidence suggest that mast cells could also play a role in the pathogenesis of both the human and murine disease. Using a myelin oligodendrocyte glycoprotein (MOG)-induced model of acute EAE, we show that mast cell–deficient W/W(v) mice exhibit significantly reduced disease incidence, delayed disease onset, and decreased mean clinical scores when compared with their wild-type congenic littermates. No differences were observed in MOG-specific T and B cell responses between the two groups, indicating that a global T or B cell defect is not present in W/W(v) animals. Reconstitution of the mast cell population in W/W(v) mice restores induction of early and severe disease to wild-type levels, suggesting that mast cells are critical for the full manifestation of disease. These data provide a new mechanism for immune destruction in EAE and indicate that mast cells play a broader role in neurologic inflammation. The Rockefeller University Press 2000-03-06 /pmc/articles/PMC2195850/ /pubmed/10704463 Text en © 2000 government This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Original Article Secor, Virginia H. Secor, W. Evan Gutekunst, Claire-Anne Brown, Melissa A. Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis |
title | Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis |
title_full | Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis |
title_fullStr | Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis |
title_full_unstemmed | Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis |
title_short | Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis |
title_sort | mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195850/ https://www.ncbi.nlm.nih.gov/pubmed/10704463 |
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