Deficiency of the Stress Kinase P38α Results in Embryonic Lethality: Characterization of the Kinase Dependence of Stress Responses of Enzyme-Deficient Embryonic Stem Cells

The mitogen-activated protein (MAP) kinase p38 is a key component of stress response pathways and the target of cytokine-suppressing antiinflammatory drugs (CSAIDs). A genetic approach was employed to inactivate the gene encoding one p38 isoform, p38α. Mice null for the p38α allele die during embryo...

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Detalles Bibliográficos
Autores principales: Allen, Melanie, Svensson, Linne, Roach, Marsha, Hambor, John, McNeish, John, Gabel, Christopher A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195860/
https://www.ncbi.nlm.nih.gov/pubmed/10704466

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