T Helper Cell Type 2 Cytokines Coordinately Regulate Immunoglobulin E–Dependent Cysteinyl Leukotriene Production by Human Cord Blood–Derived Mast Cells: Profound Induction of Leukotriene C(4) Synthase Expression by Interleukin 4

Human mast cells (hMCs) derived in vitro from cord blood mononuclear cells exhibit stem cell factor (SCF)-dependent comitogenic responses to T helper cell type 2 (Th2) cytokines. As cysteinyl leukotriene (cys-LT) biosynthesis is a characteristic of immunoglobulin (Ig)E-activated mucosal hMCs, we spe...

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Detalles Bibliográficos
Autores principales: Hsieh, Fred H., Lam, Bing K., Penrose, John F., Austen, K. Frank, Boyce, Joshua A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
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Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195887/
https://www.ncbi.nlm.nih.gov/pubmed/11136826

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