Bcl-2 Cooperates with Promyelocytic Leukemia Retinoic Acid Receptor α Chimeric Protein (Pmlrarα) to Block Neutrophil Differentiation and Initiate Acute Leukemia

The promyelocytic leukemia retinoic acid receptor α (PMLRARα) chimeric protein is associated with acute promyelocytic leukemia (APL). PMLRARα transgenic mice develop leukemia only after several months, suggesting that PMLRARα does not by itself confer a fully malignant phenotype. Suppression of apop...

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Detalles Bibliográficos
Autores principales: Kogan, Scott C., Brown, Diane E., Shultz, David B., Truong, Bao-Tran H., Lallemand-Breitenbach, Valerie, Guillemin, Marie-Claude, Lagasse, Eric, Weissman, Irving L., Bishop, J. Michael
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195904/
https://www.ncbi.nlm.nih.gov/pubmed/11181704

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