Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

In T cells, cAMP-dependent protein kinase (PKA) type I colocalizes with the T cell receptor–CD3 complex (TCR/CD3) and inhibits T cell function via a previously unknown proximal target. Here we examine the mechanism for this PKA-mediated immunomodulation. cAMP treatment of Jurkat and normal T cells r...

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Detalles Bibliográficos
Autores principales: Vang, Torkel, Torgersen, Knut Martin, Sundvold, Vibeke, Saxena, Manju, Levy, Finn Olav, Skålhegg, Bjørn S., Hansson, Vidar, Mustelin, Tomas, Taskén, Kjetil
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195911/
https://www.ncbi.nlm.nih.gov/pubmed/11181701

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