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Impairment of Cd4(+) T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants

We have shown previously that neutralizing antibodies (nAbs) are important contributors to the long-term immune control of lymphocytic choriomeningitis virus infection, particularly if cytotoxic T cell responses are low or absent. Nevertheless, virus escape from the nAb response due to mutations wit...

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Autores principales: Ciurea, Adrian, Hunziker, Lukas, Klenerman, Paul, Hengartner, Hans, Zinkernagel, Rolf M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195917/
https://www.ncbi.nlm.nih.gov/pubmed/11157050
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author Ciurea, Adrian
Hunziker, Lukas
Klenerman, Paul
Hengartner, Hans
Zinkernagel, Rolf M.
author_facet Ciurea, Adrian
Hunziker, Lukas
Klenerman, Paul
Hengartner, Hans
Zinkernagel, Rolf M.
author_sort Ciurea, Adrian
collection PubMed
description We have shown previously that neutralizing antibodies (nAbs) are important contributors to the long-term immune control of lymphocytic choriomeningitis virus infection, particularly if cytotoxic T cell responses are low or absent. Nevertheless, virus escape from the nAb response due to mutations within the surface glycoprotein gene may subsequently allow the virus to persist. Here we show that most of the antibody-escape viral mutants retain their immunogenicity. We present evidence that the failure of the infected host to mount effective humoral responses against emerging neutralization-escape mutants correlates with the rapid loss of CD4(+) T cell responsiveness during the establishment of viral persistence. Similar mechanisms may contribute to the persistence of some human pathogens such as hepatitis B and C viruses, and human immunodeficiency virus.
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spelling pubmed-21959172008-04-14 Impairment of Cd4(+) T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants Ciurea, Adrian Hunziker, Lukas Klenerman, Paul Hengartner, Hans Zinkernagel, Rolf M. J Exp Med Original Article We have shown previously that neutralizing antibodies (nAbs) are important contributors to the long-term immune control of lymphocytic choriomeningitis virus infection, particularly if cytotoxic T cell responses are low or absent. Nevertheless, virus escape from the nAb response due to mutations within the surface glycoprotein gene may subsequently allow the virus to persist. Here we show that most of the antibody-escape viral mutants retain their immunogenicity. We present evidence that the failure of the infected host to mount effective humoral responses against emerging neutralization-escape mutants correlates with the rapid loss of CD4(+) T cell responsiveness during the establishment of viral persistence. Similar mechanisms may contribute to the persistence of some human pathogens such as hepatitis B and C viruses, and human immunodeficiency virus. The Rockefeller University Press 2001-02-05 /pmc/articles/PMC2195917/ /pubmed/11157050 Text en © 2001 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Original Article
Ciurea, Adrian
Hunziker, Lukas
Klenerman, Paul
Hengartner, Hans
Zinkernagel, Rolf M.
Impairment of Cd4(+) T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants
title Impairment of Cd4(+) T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants
title_full Impairment of Cd4(+) T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants
title_fullStr Impairment of Cd4(+) T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants
title_full_unstemmed Impairment of Cd4(+) T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants
title_short Impairment of Cd4(+) T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants
title_sort impairment of cd4(+) t cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195917/
https://www.ncbi.nlm.nih.gov/pubmed/11157050
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