Impairment of Cd4(+) T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants

We have shown previously that neutralizing antibodies (nAbs) are important contributors to the long-term immune control of lymphocytic choriomeningitis virus infection, particularly if cytotoxic T cell responses are low or absent. Nevertheless, virus escape from the nAb response due to mutations wit...

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Detalles Bibliográficos
Autores principales: Ciurea, Adrian, Hunziker, Lukas, Klenerman, Paul, Hengartner, Hans, Zinkernagel, Rolf M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195917/
https://www.ncbi.nlm.nih.gov/pubmed/11157050

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