C-Jun Nh(2)-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

Apoptotic and mitogenic stimuli activate c-Jun NH(2)-terminal kinases (JNKs) in T cells. Although T cells express both JNK1 and JNK2 isozymes, the absence of JNK2 alone can result in resistance to anti-CD3–induced thymocyte apoptosis and defective mature T cell proliferation. Similar defects in thym...

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Detalles Bibliográficos
Autores principales: Sabapathy, Kanaga, Kallunki, Tuula, David, Jean-Pierre, Graef, Isabella, Karin, Michael, Wagner, Erwin F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195924/
https://www.ncbi.nlm.nih.gov/pubmed/11157052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195924/
https://www.ncbi.nlm.nih.gov/pubmed/11157052

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