Cargando…

Cd8 Expression up to the Double-Positive CD3(Low/Intermediate) Stage of Thymic Differentiation Is Sufficient for Development of Peripheral Functional Cytotoxic T Lymphocytes

Control of CD8α transcription during development of α/β T cell receptor (TCR) T lymphocytes is mediated by at least two distinct stage-specific cis-acting transcriptional mechanisms (i.e., enhancers). On the CD8α(−/)−knockout (KO) background, cis-mechanism I and cis-mechanism II together mediate app...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, X.-L., Zhao, S., Borenstein, S.H., Liu, Y., Jayabalasingham, B., Chamberlain, J.W.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2001
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195943/ https://www.ncbi.nlm.nih.gov/pubmed/11535636

Ejemplares similares

Role of CD8 in Aberrant Function of Cytotoxic T Lymphocytes
por: Kessler, Benedikt, et al.
Publicado: (1997)

Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo
por: Lee, Delphine J., et al.
Publicado: (1998)

CD40-deficient, Influenza-specific CD8 Memory T Cells Develop and Function Normally in a CD40-sufficient Environment
por: Lee, Byung O., et al.
Publicado: (2003)

Immunologic Self-Tolerance Maintained by Cd25(+)Cd4(+)Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
por: Takahashi, Takeshi, et al.
Publicado: (2000)

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8(+) T Cells Independently of CD4(+)T Cell Help
por: McCoy, Kathy D., et al.
Publicado: (1999)

Asynchronous Coreceptor Downregulation after Positive Thymic Selection: Prolonged Maintenance of the Double Positive State in CD8 Lineage Differentiation Due to Sustained Biosynthesis of the CD4 Coreceptor
por: Barthlott, Thomas, et al.
Publicado: (1997)

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25(+)Cd4(+) Regulatory Cells That Control Intestinal Inflammation
por: Read, Simon, et al.
Publicado: (2000)

MHC Class II Expression Restricted to CD8α(+) and CD11b(+) Dendritic Cells Is Sufficient for Control of Leishmania major
por: Lemos, Maria P., et al.
Publicado: (2004)

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

Cytotoxic T Lymphocyte Antigen 4 and CD28 Modulate Cell Surface Raft Expression in Their Regulation of T Cell Function
por: Martin, Margarita, et al.
Publicado: (2001)

B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28
por: Fallarino, Francesca, et al.
Publicado: (1998)

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28
por: Lin, Hua, et al.
Publicado: (1998)

Intestinal CD8αα IELs derived from two distinct thymic precursors have staggered ontogeny
por: Ruscher, Roland, et al.
Publicado: (2020)

Immature Dendritic Cells Acquire Cd8(+)Cytotoxic T Lymphocyte Priming Capacity upon Activation by T Helper Cell–Independent or–Dependent Stimuli
por: Schuurhuis, Danita H., et al.
Publicado: (2000)

DNA Double-Strand Breaks: Prior to but not Sufficient in Targeting Hypermutation
por: Bross, Linda, et al.
Publicado: (2002)

Essential and Partially Overlapping Role of CD3γ and CD3δ for Development of αβ and γδ T Lymphocytes
por: Wang, Baoping, et al.
Publicado: (1998)

Productive Infection of Neonatal CD8(+) T Lymphocytes by HIV-1
por: Yang, Liang Peng, et al.
Publicado: (1998)

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4(+) T lymphocytes by CD4(+) CD25(+) regulatory T cells
por: Bopp, Tobias, et al.
Publicado: (2005)

Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation
por: Jenkinson, S. Rhiannon, et al.
Publicado: (2007)

RANK signals from CD4(+)3(−) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
por: Rossi, Simona W., et al.
Publicado: (2007)

Human CD4(+) T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function
por: Haines, Christopher J., et al.
Publicado: (2009)

In Vivo Cytotoxic T Lymphocyte Elicitation by Mycobacterial Heat Shock Protein 70 Fusion Proteins Maps to a Discrete Domain and Is Cd4(+) T Cell Independent
por: Huang, Qian, et al.
Publicado: (2000)

Niche-specific MHC II and PD-L1 regulate CD4(+)CD8αα(+) intraepithelial lymphocyte differentiation
por: Moon, Sookjin, et al.
Publicado: (2021)

The clone size of peripheral CD8 T cells is regulated by TCR promiscuity
por: Hao, Yi, et al.
Publicado: (2006)

Chronic Restraint Stress Promotes Lymphocyte Apoptosis by Modulating Cd95 Expression
por: Yin, Deling, et al.
Publicado: (2000)

CYTOTOXIC THYMUS-DERIVED LYMPHOCYTES IN CEREBROSPINAL FLUID OF MICE WITH LYMPHOCYTIC CHORIOMENINGITIS
por: Zinkernagel, R. M., et al.
Publicado: (1973)

Normal Lymphocyte Development but Delayed Humoral Immune Response in CD81-null Mice
por: Maecker, Holden T., et al.
Publicado: (1997)

Human Dendritic Cells Activated by TSLP and CD40L Induce Proallergic Cytotoxic T Cells
por: Gilliet, Michel, et al.
Publicado: (2003)

The Peripheral Deletion of Autoreactive CD8(+) T Cells Induced by Cross-presentation of Self-antigens Involves Signaling through CD95 (Fas, Apo-1)
por: Kurts, Christian, et al.
Publicado: (1998)

CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation
por: Ehirchiou, Driss, et al.
Publicado: (2007)

CD1d-restricted Help To B Cells By Human Invariant Natural Killer T Lymphocytes
por: Galli, Grazia, et al.
Publicado: (2003)

GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment
por: Wang, Xiaoming, et al.
Publicado: (2014)

Thymic emigration revisited
por: McCaughtry, Tom M., et al.
Publicado: (2007)

ROLE OF H-2 LYMPHOCYTE-DEFINED AND SEROLOGICALLY-DEFINED COMPONENTS IN THE GENERATION OF CYTOTOXIC LYMPHOCYTES
por: Alter, Barbara J., et al.
Publicado: (1974)

B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency
por: Gupta, Vikas A., et al.
Publicado: (2008)

AIDS virus–specific CD8(+) T lymphocytes against an immunodominant cryptic epitope select for viral escape
por: Maness, Nicholas J., et al.
Publicado: (2007)

A nonclassical non-Vα14Jα18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance
por: Terabe, Masaki, et al.
Publicado: (2005)

The CD8α(+) Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens
por: Belz, Gabrielle T., et al.
Publicado: (2002)

Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes
por: Chen, Mei Lan, et al.
Publicado: (2020)

Restoration of CD28 Expression in CD28(−) CD8(+) Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production
por: Topp, Max S., et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_rbeh38sjvsha7127tt0fnsv1i9