Oral but Not Parenteral Interleukin (IL)-12 Redirects T Helper 2 (Th2)-type Responses to an Oral Vaccine Without Altering Mucosal IgA Responses

Our past studies have shown that the mucosal adjuvant cholera toxin (CT) induces T helper type 2 (Th2) responses with systemic IgG1, IgE and mucosal secretory IgA (S-IgA) antibodies (Abs). In this study, recombinant murine IL-12 (rmIL-12) was given either parenterally or orally to mice orally immuni...

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Detalles Bibliográficos
Autores principales: Marinaro, Mariarosaria, Boyaka, Prosper N., Finkelman, Fred D., Kiyono, Hiroshi, Jackson, Raymond J., Jirillo, Emilio, McGhee, Jerry R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196042/
https://www.ncbi.nlm.nih.gov/pubmed/9053442

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