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Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification

Nonreciprocal translocations and gene amplifications are commonly found in human tumors. Although little is known about the mechanisms leading to such aberrations, tissue culture models predict that they can arise from DNA breakage, followed by cycles of chromatid fusion, asymmetric mitotic breakage...

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Detalles Bibliográficos
Autores principales:	Difilippantonio, Michael J., Petersen, Simone, Chen, Hua Tang, Johnson, Roger, Jasin, Maria, Kanaar, Roland, Ried, Thomas, Nussenzweig, André
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196056/ https://www.ncbi.nlm.nih.gov/pubmed/12186839 http://dx.doi.org/10.1084/jem.20020851

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