Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8(+) T Cell Tolerance

To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues. Ovalbumin (OVA) protein, when chemically coupled to monoclonal αDEC...

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Detalles Bibliográficos
Autores principales: Bonifaz, Laura, Bonnyay, David, Mahnke, Karsten, Rivera, Miguel, Nussenzweig, Michel C., Steinman, Ralph M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196060/
https://www.ncbi.nlm.nih.gov/pubmed/12486105
http://dx.doi.org/10.1084/jem.20021598

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