Bruton's Tyrosine Kinase Cooperates with the B Cell Linker Protein SLP-65 as a Tumor Suppressor in Pre-B Cells

Expression of the pre-B cell receptor (pre-BCR) leads to activation of the adaptor molecule SLP-65 and the cytoplasmic kinase Btk. Mice deficient for one of these signaling proteins have an incomplete block in B cell development at the stage of large cycling pre-BCR(+)CD43(+) pre-B cells. Our recent...

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Detalles Bibliográficos
Autores principales: Kersseboom, Rogier, Middendorp, Sabine, Dingjan, Gemma M., Dahlenborg, Katarina, Reth, Michael, Jumaa, Hassan, Hendriks, Rudolf W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196076/
https://www.ncbi.nlm.nih.gov/pubmed/12835482
http://dx.doi.org/10.1084/jem.20030615

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