Cargando…

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) is mediated by autoantigen-specific T cells dependent on critical costimulatory signals for their full activation and regulation. We report that the programmed death-1 (PD-1) costimulatory pathway plays a critical role in regulating peripheral toleranc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salama, Alan D., Chitnis, Tanuja, Imitola, Jaime, Ansari, Mohammed Javeed I., Akiba, Hisaya, Tushima, Fumihiko, Azuma, Miyuki, Yagita, Hideo, Sayegh, Mohamed H., Khoury, Samia J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196082/ https://www.ncbi.nlm.nih.gov/pubmed/12847138 http://dx.doi.org/10.1084/jem.20022119

Ejemplares similares

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice
por: Ansari, Mohammed Javeed I., et al.
Publicado: (2003)

A critical role for the programmed death ligand 1 in fetomaternal tolerance
por: Guleria, Indira, et al.
Publicado: (2005)

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway
por: Fife, Brian T., et al.
Publicado: (2006)

Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function
por: Xiao, Sheng, et al.
Publicado: (2007)

Depletion of PD-1-positive cells ameliorates autoimmune disease
por: Zhao, Peng, et al.
Publicado: (2019)

Cooperative B7-1/2 (CD80/CD86) and B7-DC Costimulation of CD4(+) T Cells Independent of the PD-1 Receptor
por: Shin, Tahiro, et al.
Publicado: (2003)

Role of the PD‐1/PD‐L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions
por: Mi, Yan, et al.
Publicado: (2021)

Contribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis
por: Lutz, Sarah E., et al.
Publicado: (2013)

PD‐1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state
por: Mair, Iris, et al.
Publicado: (2018)

Correction: Contribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis
por: Lutz, Sarah E., et al.
Publicado: (2013)

Special AT‐rich sequence binding protein 1 is required for maintenance of T cell receptor responsiveness and development of experimental autoimmune encephalomyelitis
por: Akiba, Yasushi, et al.
Publicado: (2018)

PD-1, but Not PD-L1, Expressed by Islet-Reactive CD4(+) T Cells Suppresses Infiltration of the Pancreas During Type 1 Diabetes
por: Pauken, Kristen E., et al.
Publicado: (2013)

Blockade of PD-1/PD-L1 Promotes Adoptive T-Cell Immunotherapy in a Tolerogenic Environment
por: Blake, Stephen J. P., et al.
Publicado: (2015)

Modulation of experimental autoimmune encephalomyelitis by endogenous Annexin A1
por: Paschalidis, Nikolaos, et al.
Publicado: (2009)

Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis
por: Sánchez-Fernández, Alba, et al.
Publicado: (2022)

Galectin-9-Mediated Protection from Allo-Specific T Cells as a Mechanism of Immune Privilege of Corneal Allografts
por: Shimmura-Tomita, Machiko, et al.
Publicado: (2013)

Lactobacillus helveticus SBT2171 Attenuates Experimental Autoimmune Encephalomyelitis in Mice
por: Yamashita, Maya, et al.
Publicado: (2018)

Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation
por: Imitola, Jaime, et al.
Publicado: (2023)

Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis
por: Bettelli, Estelle, et al.
Publicado: (2004)

Delayed Onset of Experimental Autoimmune Encephalomyelitis in Olig1 Deficient Mice
por: Guo, Xiaoli, et al.
Publicado: (2010)

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine
por: Paris, Daniel, et al.
Publicado: (2013)

Environmental Influences in Experimental Autoimmune Encephalomyelitis
por: Constantinescu, Cris S
Publicado: (2005)

Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells
por: Tripathi, Sudipta, et al.
Publicado: (2015)

Th2 Cell-Intrinsic Hypo-Responsiveness Determines Susceptibility to Helminth Infection
por: van der Werf, Nienke, et al.
Publicado: (2013)

TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance
por: Baas, Marije, et al.
Publicado: (2016)

Natural Killer T-Cell Agonist α-Galactosylceramide and PD-1 Blockade Synergize to Reduce Tumor Development in a Preclinical Model of Colon Cancer
por: Wang, Ying, et al.
Publicado: (2020)

Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells
por: Kawamoto, Toshio, et al.
Publicado: (2011)

NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis
por: Reppert, Sarah, et al.
Publicado: (2015)

Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis
por: Didonna, Alessandro, et al.
Publicado: (2020)

Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation
por: Horiuchi, Hiroshi, et al.
Publicado: (2021)

PD-1/PD-L1 Inhibitors in Patients With Preexisting Autoimmune Diseases
por: Zhang, Ke, et al.
Publicado: (2022)

Regulation of Immune Responses and Autoimmune Encephalomyelitis by PPARs
por: Yang, Yuhong, et al.
Publicado: (2010)

Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis
por: Girolamo, Francesco, et al.
Publicado: (2014)

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
por: Basler, Michael, et al.
Publicado: (2014)

The Role of ERK Signaling in Experimental Autoimmune Encephalomyelitis
por: Birkner, Katharina, et al.
Publicado: (2017)

Amelioration of experimental autoimmune encephalomyelitis by Ishige okamurae
por: Ahn, Meejung, et al.
Publicado: (2018)

Oryeongsan (Goreisan) Ameliorates Experimental Autoimmune Encephalomyelitis
por: Inada, Rino, et al.
Publicado: (2019)

Opposing T Cell Responses in Experimental Autoimmune Encephalomyelitis
por: Saligrama, Naresha, et al.
Publicado: (2019)

Molecular effects of curcumin on the experimental autoimmune encephalomyelitis
por: Mavaddatiyan, Laleh, et al.
Publicado: (2021)

Association between PD-L1 expression combined with tumor-infiltrating lymphocytes and the prognosis of patients with advanced hypopharyngeal squamous cell carcinoma
por: Ono, Takeharu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hn7qhqceqet1d9r6nfhhh8juh4