Follicular Dendritic Cells Specifically Express the Long CR2/CD21 Isoform

This paper describes an antibody (mAb 7D6) that specifically recognizes human follicular dendritic cells (FDCs). By expression cloning, a cDNA clone encoding for the long human CR2/ CD21 isoform (CD21L) that contains an additional exon (10a) was isolated. We demonstrated that FDCs selectively expres...

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Detalles Bibliográficos
Autores principales: Liu, Yong-Jun, Xu, Jiangchun, de Bouteiller, Odette, Parham, Christi L., Grouard, Géraldine, Djossou, Odile, de Saint-Vis, Blandine, Lebecque, Serge, Banchereau, Jacques, Moore, Kevin W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196095/
https://www.ncbi.nlm.nih.gov/pubmed/8996252
Descripción
Sumario:This paper describes an antibody (mAb 7D6) that specifically recognizes human follicular dendritic cells (FDCs). By expression cloning, a cDNA clone encoding for the long human CR2/ CD21 isoform (CD21L) that contains an additional exon (10a) was isolated. We demonstrated that FDCs selectively express CD21L, while B cells selectively express the short CR2/CD21 lacking exon 10a (CD21S). By screening mouse Ltk(−) cells transfected with the CD21L cDNA, we further showed that the other two anti–human FDC mAbs DRC-1 and KiM4 also recognize CD21L. Thus, CD21L represents the first characterized human FDC-specific molecule, which may confer unique functions of FDCs in germinal center development.

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