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CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia

CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons for the existence of two CD28 binding molecules are not well understood. We created a mutant version of CTLA4-Ig that co...

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Autores principales: Harris, Nicola, Peach, Robert, Naemura, Joe, Linsley, Peter S., Le Gros, Graham, Ronchese, Franca
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196101/
https://www.ncbi.nlm.nih.gov/pubmed/8996254
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author Harris, Nicola
Peach, Robert
Naemura, Joe
Linsley, Peter S.
Le Gros, Graham
Ronchese, Franca
author_facet Harris, Nicola
Peach, Robert
Naemura, Joe
Linsley, Peter S.
Le Gros, Graham
Ronchese, Franca
author_sort Harris, Nicola
collection PubMed
description CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons for the existence of two CD28 binding molecules are not well understood. We created a mutant version of CTLA4-Ig that could selectively bind CD80 and block CD28-CD80 interaction but leave CD28-CD86 binding intact. CD80 blockade prevented antigen-induced accumulation of eosinophils and lymphocytes in the lung of immunized mice, but did not block antigen induced systemic blood eosinophilia or IgE antibody production. No preferential expression of CD80 could be demonstrated on a population of lung APC consisting mainly of macrophages. These results indicate that CD80 costimulation is not necessary for the induction of Th2 immune responses but rather for the maintenance or amplification of lung inflammatory responses.
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spelling pubmed-21961012008-04-16 CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia Harris, Nicola Peach, Robert Naemura, Joe Linsley, Peter S. Le Gros, Graham Ronchese, Franca J Exp Med Brief Definitive Report CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons for the existence of two CD28 binding molecules are not well understood. We created a mutant version of CTLA4-Ig that could selectively bind CD80 and block CD28-CD80 interaction but leave CD28-CD86 binding intact. CD80 blockade prevented antigen-induced accumulation of eosinophils and lymphocytes in the lung of immunized mice, but did not block antigen induced systemic blood eosinophilia or IgE antibody production. No preferential expression of CD80 could be demonstrated on a population of lung APC consisting mainly of macrophages. These results indicate that CD80 costimulation is not necessary for the induction of Th2 immune responses but rather for the maintenance or amplification of lung inflammatory responses. The Rockefeller University Press 1997-01-06 /pmc/articles/PMC2196101/ /pubmed/8996254 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Report
Harris, Nicola
Peach, Robert
Naemura, Joe
Linsley, Peter S.
Le Gros, Graham
Ronchese, Franca
CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
title CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
title_full CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
title_fullStr CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
title_full_unstemmed CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
title_short CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
title_sort cd80 costimulation is essential for the induction of airway eosinophilia
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196101/
https://www.ncbi.nlm.nih.gov/pubmed/8996254
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