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CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons for the existence of two CD28 binding molecules are not well understood. We created a mutant version of CTLA4-Ig that co...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1997
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196101/ https://www.ncbi.nlm.nih.gov/pubmed/8996254 |
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author | Harris, Nicola Peach, Robert Naemura, Joe Linsley, Peter S. Le Gros, Graham Ronchese, Franca |
author_facet | Harris, Nicola Peach, Robert Naemura, Joe Linsley, Peter S. Le Gros, Graham Ronchese, Franca |
author_sort | Harris, Nicola |
collection | PubMed |
description | CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons for the existence of two CD28 binding molecules are not well understood. We created a mutant version of CTLA4-Ig that could selectively bind CD80 and block CD28-CD80 interaction but leave CD28-CD86 binding intact. CD80 blockade prevented antigen-induced accumulation of eosinophils and lymphocytes in the lung of immunized mice, but did not block antigen induced systemic blood eosinophilia or IgE antibody production. No preferential expression of CD80 could be demonstrated on a population of lung APC consisting mainly of macrophages. These results indicate that CD80 costimulation is not necessary for the induction of Th2 immune responses but rather for the maintenance or amplification of lung inflammatory responses. |
format | Text |
id | pubmed-2196101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21961012008-04-16 CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia Harris, Nicola Peach, Robert Naemura, Joe Linsley, Peter S. Le Gros, Graham Ronchese, Franca J Exp Med Brief Definitive Report CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons for the existence of two CD28 binding molecules are not well understood. We created a mutant version of CTLA4-Ig that could selectively bind CD80 and block CD28-CD80 interaction but leave CD28-CD86 binding intact. CD80 blockade prevented antigen-induced accumulation of eosinophils and lymphocytes in the lung of immunized mice, but did not block antigen induced systemic blood eosinophilia or IgE antibody production. No preferential expression of CD80 could be demonstrated on a population of lung APC consisting mainly of macrophages. These results indicate that CD80 costimulation is not necessary for the induction of Th2 immune responses but rather for the maintenance or amplification of lung inflammatory responses. The Rockefeller University Press 1997-01-06 /pmc/articles/PMC2196101/ /pubmed/8996254 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Definitive Report Harris, Nicola Peach, Robert Naemura, Joe Linsley, Peter S. Le Gros, Graham Ronchese, Franca CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia |
title | CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia |
title_full | CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia |
title_fullStr | CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia |
title_full_unstemmed | CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia |
title_short | CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia |
title_sort | cd80 costimulation is essential for the induction of airway eosinophilia |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196101/ https://www.ncbi.nlm.nih.gov/pubmed/8996254 |
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