Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo

Evidence is provided that proteolytic cleavage of collagen type IV results in the exposure of a functionally important cryptic site hidden within its triple helical structure. Exposure of this cryptic site was associated with angiogenic, but not quiescent, blood vessels and was required for angiogen...

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Detalles Bibliográficos
Autores principales: Xu, Jingsong, Rodriguez, Dorothy, Petitclerc, Eric, Kim, Jenny J., Hangai, Masanori, Yuen, S. Moon, Davis, George E., Brooks, Peter C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196184/
https://www.ncbi.nlm.nih.gov/pubmed/11535623
http://dx.doi.org/10.1083/jcb.200103111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196184/
https://www.ncbi.nlm.nih.gov/pubmed/11535623
http://dx.doi.org/10.1083/jcb.200103111

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