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Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo
Evidence is provided that proteolytic cleavage of collagen type IV results in the exposure of a functionally important cryptic site hidden within its triple helical structure. Exposure of this cryptic site was associated with angiogenic, but not quiescent, blood vessels and was required for angiogen...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2001
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196184/ https://www.ncbi.nlm.nih.gov/pubmed/11535623 http://dx.doi.org/10.1083/jcb.200103111 |