A new view of the spindle checkpoint

Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far...

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Detalles Bibliográficos
Autor principal: Hoyt, M. Andrew
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196198/
https://www.ncbi.nlm.nih.gov/pubmed/11535614
http://dx.doi.org/10.1083/jcb.200108010
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author Hoyt, M. Andrew
author_facet Hoyt, M. Andrew
author_sort Hoyt, M. Andrew
collection PubMed
description Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.
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spelling pubmed-21961982008-05-01 A new view of the spindle checkpoint Hoyt, M. Andrew J Cell Biol Comment Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function. The Rockefeller University Press 2001-09-03 /pmc/articles/PMC2196198/ /pubmed/11535614 http://dx.doi.org/10.1083/jcb.200108010 Text en Copyright © 2001, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Comment
Hoyt, M. Andrew
A new view of the spindle checkpoint
title A new view of the spindle checkpoint
title_full A new view of the spindle checkpoint
title_fullStr A new view of the spindle checkpoint
title_full_unstemmed A new view of the spindle checkpoint
title_short A new view of the spindle checkpoint
title_sort new view of the spindle checkpoint
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196198/
https://www.ncbi.nlm.nih.gov/pubmed/11535614
http://dx.doi.org/10.1083/jcb.200108010
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