The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand

A subset of CD4(+)CD11c(−)CD3(−) blood cells was recently shown to develop into dendritic cells when cultured with monocyte conditioned medium. Here, we demonstrate that CD4(+) CD11c(−)CD3(−) cells, isolated from tonsils, correspond to the so-called plasmacytoid T cells, an obscure cell type that ha...

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Autores principales: Grouard, Géraldine, Rissoan, Marie-Clotilde, Filgueira, Luis, Durand, Isabelle, Banchereau, Jacques, Liu, Yong-Jun
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196227/
https://www.ncbi.nlm.nih.gov/pubmed/9091583
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author Grouard, Géraldine
Rissoan, Marie-Clotilde
Filgueira, Luis
Durand, Isabelle
Banchereau, Jacques
Liu, Yong-Jun
author_facet Grouard, Géraldine
Rissoan, Marie-Clotilde
Filgueira, Luis
Durand, Isabelle
Banchereau, Jacques
Liu, Yong-Jun
author_sort Grouard, Géraldine
collection PubMed
description A subset of CD4(+)CD11c(−)CD3(−) blood cells was recently shown to develop into dendritic cells when cultured with monocyte conditioned medium. Here, we demonstrate that CD4(+) CD11c(−)CD3(−) cells, isolated from tonsils, correspond to the so-called plasmacytoid T cells, an obscure cell type that has long been observed by pathologists within secondary lymphoid tissues. They express CD45RA, but not markers specific for known lymphoid- or myeloid-derived cell types. They undergo rapid apoptosis in culture, unless rescued by IL-3. Further addition of CD40-ligand results in their differentiation into dendritic cells that express low levels of myeloid antigens CD13 and CD33.
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spelling pubmed-21962272008-04-16 The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand Grouard, Géraldine Rissoan, Marie-Clotilde Filgueira, Luis Durand, Isabelle Banchereau, Jacques Liu, Yong-Jun J Exp Med Article A subset of CD4(+)CD11c(−)CD3(−) blood cells was recently shown to develop into dendritic cells when cultured with monocyte conditioned medium. Here, we demonstrate that CD4(+) CD11c(−)CD3(−) cells, isolated from tonsils, correspond to the so-called plasmacytoid T cells, an obscure cell type that has long been observed by pathologists within secondary lymphoid tissues. They express CD45RA, but not markers specific for known lymphoid- or myeloid-derived cell types. They undergo rapid apoptosis in culture, unless rescued by IL-3. Further addition of CD40-ligand results in their differentiation into dendritic cells that express low levels of myeloid antigens CD13 and CD33. The Rockefeller University Press 1997-03-17 /pmc/articles/PMC2196227/ /pubmed/9091583 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Grouard, Géraldine
Rissoan, Marie-Clotilde
Filgueira, Luis
Durand, Isabelle
Banchereau, Jacques
Liu, Yong-Jun
The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand
title The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand
title_full The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand
title_fullStr The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand
title_full_unstemmed The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand
title_short The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand
title_sort enigmatic plasmacytoid t cells develop into dendritic cells with interleukin (il)-3 and cd40-ligand
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196227/
https://www.ncbi.nlm.nih.gov/pubmed/9091583
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