Interleukin-10 Is a Natural Suppressor of Cytokine Production and Inflammation in a Murine Model of Allergic Bronchopulmonary Aspergillosis

We have used interleukin-10 (IL-10) gene knockout mice (IL-10(−/−)) to examine the role of endogenous IL-10 in allergic lung responses to Aspergillus fumigatus Ag. In vitro restimulated lung cells from sensitized IL-10(−/−) mice produced exaggerated amounts of IL-4, IL-5, and interferon-γ (IFN-γ) co...

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Detalles Bibliográficos
Autores principales: Grünig, Gabriele, Corry, David B., Leach, Michael W., Seymour, Brian W.P., Kurup, Viswanath P., Rennick, Donna M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196229/
https://www.ncbi.nlm.nih.gov/pubmed/9091582

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