Cargando…

Aspirin-triggered 15-Epi-Lipoxin A(4) (LXA(4)) and LXA(4) Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors

Lipoxins are bioactive eicosanoids that are immunomodulators. In human myeloid cells, lipoxin (LX) A(4) actions are mediated by interaction with a G protein–coupled receptor. To explore functions of LXA(4) and aspirin-triggered 5(S),6(R),15(R)-trihydroxy-7,9,13-trans-11-cis–eicosatetraenoic acid (15...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takano, Tomoko, Fiore, Stefano, Maddox, Jane F., Brady, Hugh R., Petasis, Nicos A., Serhan, Charles N.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1997
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196289/ https://www.ncbi.nlm.nih.gov/pubmed/9151906

Ejemplares similares

Lipoxin (LX)A(4) and Aspirin-triggered 15-epi-LXA(4) Inhibit Tumor Necrosis Factor 1α–initiated Neutrophil Responses and Trafficking: Regulators of a Cytokine–Chemokine Axis
por: Hachicha, Mohamed, et al.
Publicado: (1999)

Lipoxin A4 (LXA4) Reduces Alkali-Induced Corneal Inflammation and Neovascularization and Upregulates a Repair Transcriptome
por: He, Jiucheng, et al.
Publicado: (2023)

Dynamic changes and clinical significance of LXA(4) in the perioperative period of cardiopulmonary bypass
por: Wu, Ming, et al.
Publicado: (2019)

15-Epi-LXA(4) and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture
por: Dakin, Stephanie G., et al.
Publicado: (2019)

LXA4 Inhibits Lipopolysaccharide-Induced Inflammatory Cell Accumulation by Resident Macrophages in Mice
por: Mei, Hong-Xia, et al.
Publicado: (2021)

15-Epi-LXA(4) and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation
por: Sekheri, Meriem, et al.
Publicado: (2020)

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE(2) and LXA(4) in the induction of macrophage death
por: Chen, Minjian, et al.
Publicado: (2008)

Early Production of the Neutrophil-Derived Lipid Mediators LTB(4) and LXA(4) Is Modulated by Intracellular Infection with Leishmania major
por: Plagge, Michael, et al.
Publicado: (2017)

Dietary DHA amplifies LXA(4) circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease
por: Gao, Yuan, et al.
Publicado: (2018)

LXA(4)-FPR2 signaling regulates radiation-induced pulmonary fibrosis via crosstalk with TGF-β/Smad signaling
por: Kim, Hyunjung, et al.
Publicado: (2020)

Lipid-Derived Mediators in Endogenous Anti-Inflammation and Resolution: Lipoxins and Aspirin-Triggered 15-epi-Lipoxins
por: Serhan, Charles N., et al.
Publicado: (2002)

LXA4 protects against blue-light induced retinal degeneration in human A2E-laden RPE cells and Balb-c mice
por: Xie, Tianhua, et al.
Publicado: (2021)

Activation of Lipoxin a(4) Receptors by Aspirin-Triggered Lipoxins and Select Peptides Evokes Ligand-Specific Responses in Inflammation
por: Chiang, Nan, et al.
Publicado: (2000)

Lovastatin Decreases Acute Mucosal Inflammation Via 15-epi-Lipoxin A(4)
por: Planagumà, Anna, et al.
Publicado: (2010)

Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing
por: Svensson, Camilla I., et al.
Publicado: (2007)

Lipoxin and Aspirin-Triggered Lipoxins
por: Romano, Mario
Publicado: (2010)

15-epi-lipoxin A(4)–mediated Induction of Nitric Oxide Explains How Aspirin Inhibits Acute Inflammation
por: Paul-Clark, Mark J., et al.
Publicado: (2004)

Synthesis of aromatic lactone analogues of Lipoxin A4
por: Ismael, Aya, et al.
Publicado: (2022)

Lipoxin A(4) and 15-Epi-Lipoxin A(4) Protect against Experimental Cerebral Malaria by Inhibiting IL-12/IFN-γ in the Brain
por: Shryock, Nathaniel, et al.
Publicado: (2013)

Aspirin-triggered 15-epi-lipoxin A(4) predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test
por: Kirkby, Nicholas S., et al.
Publicado: (2013)

Aspirin-triggered 15-epi-lipoxin A(4) signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation
por: Petri, Marcelo H., et al.
Publicado: (2015)

Release of cyclooxygenase-2 and lipoxin A(4) from blood leukocytes in aspirin-exacerbated respiratory disease
por: Rozsasi, Ajnacska, et al.
Publicado: (2016)

Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction
Publicado: (1996)

Resolution Agonist 15-epi-Lipoxin A(4) Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing
por: Kain, Vasundhara, et al.
Publicado: (2017)

Protective Role of Acetylsalicylic Acid in Experimental Trypanosoma cruzi Infection: Evidence of a 15-epi-Lipoxin A(4)-Mediated Effect
por: Molina-Berríos, Alfredo, et al.
Publicado: (2013)

Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin
por: Campos-Estrada, Carolina, et al.
Publicado: (2015)

15-epi-lipoxin A(4) reduces the mortality of prematurely born pups in a mouse model of infection-induced preterm birth
por: Rinaldi, S.F., et al.
Publicado: (2015)

Exogenous Pathogen and Plant 15-Lipoxygenase Initiate Endogenous Lipoxin A(4) Biosynthesis
por: Bannenberg, Gerard L., et al.
Publicado: (2004)

First stereoselective total synthesis of 4(S),5(S)-oxido-17(S)-hydroxy-6(E),8(E),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid, the biosynthetic precursor of resolvins D3 and D4
por: Nshimiyimana, Robert, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Bicyclo[1.1.1]pentane-Containing Aromatic Lipoxin A(4) Analogues
por: Owen, Benjamin, et al.
Publicado: (2022)

Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines
por: Hu, Shan, et al.
Publicado: (2012)

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6
por: Machado, Fabiana S., et al.
Publicado: (2008)

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6
por: Machado, Fabiana S., et al.
Publicado: (2009)

Dysregulation of prostaglandins, leukotrienes and lipoxin A(4) in bronchiectasis
por: Bedi, Pallavi, et al.
Publicado: (2022)

Lipoxin A(4) Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells
por: Hodges, Robin R., et al.
Publicado: (2016)

Parasite-induced Lipoxin A(4) Is an Endogenous Regulator of IL-12 Production and Immunopathology in Toxoplasma gondii Infection
por: Aliberti, Julio, et al.
Publicado: (2002)

The role of Lipoxin A4 in Cystic Fibrosis Lung Disease
por: Urbach, Valérie, et al.
Publicado: (2013)

Effect of Lipoxin A(4) on Lipopolysaccharide-Induced Endothelial Hyperpermeability
por: Pang, Huayan, et al.
Publicado: (2011)

Lipoxin A(4) activates ALX/FPR2 Receptor to Regulate Conjunctival Goblet Cell Secretion
por: Hodges, Robin R., et al.
Publicado: (2016)

Neuroprotective Effects of Lipoxin A4 in Central Nervous System Pathologies
por: Martini, Alessandra Cadete, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_21nk1f1o28jjtllnhcf9mq86dh