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Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies
Antibody responses against antibodies, such as rheumatoid factors, are found in several immunopathological diseases and may play a role in disease pathogenesis. Experience shows that they are usually difficult to induce experimentally. Antibodies specific for immunoglobulin constant regions (anti-al...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1997
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196322/ https://www.ncbi.nlm.nih.gov/pubmed/9151704 |
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author | Fehr, Thomas Bachmann, Martin F. Bucher, Etienne Kalinke, Ulrich Padova, Franco E. Di Lang, Alois B. Hengartner, Hans Zinkernagel, Rolf M. |
author_facet | Fehr, Thomas Bachmann, Martin F. Bucher, Etienne Kalinke, Ulrich Padova, Franco E. Di Lang, Alois B. Hengartner, Hans Zinkernagel, Rolf M. |
author_sort | Fehr, Thomas |
collection | PubMed |
description | Antibody responses against antibodies, such as rheumatoid factors, are found in several immunopathological diseases and may play a role in disease pathogenesis. Experience shows that they are usually difficult to induce experimentally. Antibodies specific for immunoglobulin constant regions (anti-allotypic) or for variable regions (anti-idiotypic) have been investigated in animal models; the latter have even been postulated to regulate antibody and T cell responses via network-like interactions. Why and how such anti-antibodies are induced during autoimmune diseases, has remained largely unclear. Because repetitively arranged epitopes in a paracrystalline structure of a viral envelope cross-link B cell receptors efficiently to induce a prompt T-independent IgM response, this study used immune complexes containing viruses or bacteria to evaluate the role of antigen pattern for induction of anti-antibody responses. We present evidence that antibodies bound to strictly ordered, but not to irregularly arranged, antigens dramatically enhance induction of anti-antibodies, already after a single immunization and without using adjuvants. The results indicate a novel link between anti-antibody responses and infectious agents, and suggest a similar role for repetitive self-antigens such as DNA or collagen involved in chronic immunopathological diseases. |
format | Text |
id | pubmed-2196322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21963222008-04-16 Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies Fehr, Thomas Bachmann, Martin F. Bucher, Etienne Kalinke, Ulrich Padova, Franco E. Di Lang, Alois B. Hengartner, Hans Zinkernagel, Rolf M. J Exp Med Article Antibody responses against antibodies, such as rheumatoid factors, are found in several immunopathological diseases and may play a role in disease pathogenesis. Experience shows that they are usually difficult to induce experimentally. Antibodies specific for immunoglobulin constant regions (anti-allotypic) or for variable regions (anti-idiotypic) have been investigated in animal models; the latter have even been postulated to regulate antibody and T cell responses via network-like interactions. Why and how such anti-antibodies are induced during autoimmune diseases, has remained largely unclear. Because repetitively arranged epitopes in a paracrystalline structure of a viral envelope cross-link B cell receptors efficiently to induce a prompt T-independent IgM response, this study used immune complexes containing viruses or bacteria to evaluate the role of antigen pattern for induction of anti-antibody responses. We present evidence that antibodies bound to strictly ordered, but not to irregularly arranged, antigens dramatically enhance induction of anti-antibodies, already after a single immunization and without using adjuvants. The results indicate a novel link between anti-antibody responses and infectious agents, and suggest a similar role for repetitive self-antigens such as DNA or collagen involved in chronic immunopathological diseases. The Rockefeller University Press 1997-05-19 /pmc/articles/PMC2196322/ /pubmed/9151704 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Fehr, Thomas Bachmann, Martin F. Bucher, Etienne Kalinke, Ulrich Padova, Franco E. Di Lang, Alois B. Hengartner, Hans Zinkernagel, Rolf M. Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies |
title | Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies |
title_full | Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies |
title_fullStr | Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies |
title_full_unstemmed | Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies |
title_short | Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies |
title_sort | role of repetitive antigen patterns for induction of antibodies against antibodies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196322/ https://www.ncbi.nlm.nih.gov/pubmed/9151704 |
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