Nuclear pore complexes: dynamics in unexpected places

In vivo studies on the dynamics of the nuclear pore complex (NPC) in yeast suggested that NPCs are highly mobile in the nuclear envelope. However, new evidence indicates that in mammalian cells NPCs are stably attached to a flexible lamina framework, but a peripheral component can exchange rapidly w...

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Detalles Bibliográficos
Autores principales: Lyman, Susan K., Gerace, Larry
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196851/
https://www.ncbi.nlm.nih.gov/pubmed/11448985
http://dx.doi.org/10.1083/jcb.200106071
Descripción
Sumario:In vivo studies on the dynamics of the nuclear pore complex (NPC) in yeast suggested that NPCs are highly mobile in the nuclear envelope. However, new evidence indicates that in mammalian cells NPCs are stably attached to a flexible lamina framework, but a peripheral component can exchange rapidly with an intranuclear pool.

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