Protein Kinase C Activation Promotes Microtubule Advance in Neuronal Growth Cones by Increasing Average Microtubule Growth Lifetimes

We describe a novel mechanism for protein kinase C regulation of axonal microtubule invasion of growth cones. Activation of PKC by phorbol esters resulted in a rapid, robust advance of distal microtubules (MTs) into the F-actin rich peripheral domain of growth cones, where they are normally excluded...

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Detalles Bibliográficos
Autores principales: Kabir, Nurul, Schaefer, Andrew W., Nakhost, Arash, Sossin, Wayne S., Forscher, Paul
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198821/
https://www.ncbi.nlm.nih.gov/pubmed/11238458

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