Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

Specificity of protein ubiquitylation is conferred by E3 ubiquitin (Ub) ligases. We have annotated ∼617 putative E3s and substrate-recognition subunits of E3 complexes encoded in the human genome. The limited knowledge of the function of members of the large E3 superfamily prompted us to generate ge...

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Detalles Bibliográficos
Autores principales: Li, Wei, Bengtson, Mario H., Ulbrich, Axel, Matsuda, Akio, Reddy, Venkateshwar A., Orth, Anthony, Chanda, Sumit K., Batalov, Serge, Joazeiro, Claudio A. P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198940/
https://www.ncbi.nlm.nih.gov/pubmed/18213395
http://dx.doi.org/10.1371/journal.pone.0001487

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