Mammalian Cells Change Volume during Mitosis

Using single cell-imaging methods we have found that the volume of adherent cells grown in culture decreases as the cells rounds when it enters mitosis. A minimal volume is reached at metaphase. Rapid volume recovery initiates before abscission as cells make the transition from metaphase to cytokine...

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Detalles Bibliográficos
Autores principales: Boucrot, Emmanuel, Kirchhausen, Tomas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198941/
https://www.ncbi.nlm.nih.gov/pubmed/18213385
http://dx.doi.org/10.1371/journal.pone.0001477
Descripción
Sumario:Using single cell-imaging methods we have found that the volume of adherent cells grown in culture decreases as the cells rounds when it enters mitosis. A minimal volume is reached at metaphase. Rapid volume recovery initiates before abscission as cells make the transition from metaphase to cytokinesis. These volume changes are simultaneous with the rapid surface area decrease and recovery observed in mitotic cells [1].

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