HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication

Ligation of CCR5 by the CC chemokines RANTES, MIP-1α or MIP-1β, and of CXCR4 by the CXC chemokine SDF-1α, profoundly inhibits the replication of HIV strains that use these coreceptors for entry into CD4(+) T lymphocytes. The mechanism of entry inhibition is not known. We found a rapid and extensive...

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Detalles Bibliográficos
Autores principales: Amara, Ali, Gall, Sylvie Le, Schwartz, Olivier, Salamero, Jean, Montes, Monica, Loetscher, Pius, Baggiolini, Marco, Virelizier, Jean-Louis, Arenzana-Seisdedos, Fernando
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198965/
https://www.ncbi.nlm.nih.gov/pubmed/9207008

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