Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade

The recent observation that neutralization or genetic deletion of the T lymphocyte receptor CTLA-4 allows enhanced T cell reactivity offers new opportunities for immunotherapy against infectious agents. We used a neutralizing antibody to block CTLA-4 interaction with its ligands CD80 and CD86 during...

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Detalles Bibliográficos
Autores principales: McCoy, Kathy, Camberis, Mali, Gros, Graham Le
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198990/
https://www.ncbi.nlm.nih.gov/pubmed/9221747
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author McCoy, Kathy
Camberis, Mali
Gros, Graham Le
author_facet McCoy, Kathy
Camberis, Mali
Gros, Graham Le
author_sort McCoy, Kathy
collection PubMed
description The recent observation that neutralization or genetic deletion of the T lymphocyte receptor CTLA-4 allows enhanced T cell reactivity offers new opportunities for immunotherapy against infectious agents. We used a neutralizing antibody to block CTLA-4 interaction with its ligands CD80 and CD86 during infection of mice with the nematode, Nippostrongylus brasiliensis. CTLA-4 blockade greatly enhanced and accelerated the T cell immune response to N. brasiliensis, resulting in a profound reduction in adult worm numbers and early termination of parasite egg production. The ability of CTLA-4 blockade to accelerate primary immune responses to a protective level during an acute infection indicates its potential as an immunotherapeutic tool for dealing with infectious agents.
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spelling pubmed-21989902008-04-16 Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade McCoy, Kathy Camberis, Mali Gros, Graham Le J Exp Med Article The recent observation that neutralization or genetic deletion of the T lymphocyte receptor CTLA-4 allows enhanced T cell reactivity offers new opportunities for immunotherapy against infectious agents. We used a neutralizing antibody to block CTLA-4 interaction with its ligands CD80 and CD86 during infection of mice with the nematode, Nippostrongylus brasiliensis. CTLA-4 blockade greatly enhanced and accelerated the T cell immune response to N. brasiliensis, resulting in a profound reduction in adult worm numbers and early termination of parasite egg production. The ability of CTLA-4 blockade to accelerate primary immune responses to a protective level during an acute infection indicates its potential as an immunotherapeutic tool for dealing with infectious agents. The Rockefeller University Press 1997-07-21 /pmc/articles/PMC2198990/ /pubmed/9221747 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
McCoy, Kathy
Camberis, Mali
Gros, Graham Le
Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade
title Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade
title_full Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade
title_fullStr Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade
title_full_unstemmed Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade
title_short Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade
title_sort protective immunity to nematode infection is induced by ctla-4 blockade
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198990/
https://www.ncbi.nlm.nih.gov/pubmed/9221747
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AT camberismali protectiveimmunitytonematodeinfectionisinducedbyctla4blockade
AT grosgrahamle protectiveimmunitytonematodeinfectionisinducedbyctla4blockade

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