B Lymphocytes of Xeroderma Pigmentosum or Cockayne Syndrome Patients with Inherited Defects in Nucleotide Excision Repair Are Fully Capable of Somatic Hypermutation of Immunoglobulin Genes

Recent experiments have strongly suggested that the process of somatic mutation is linked to transcription initiation. It was postulated that a mutator factor loads onto the RNA polymerase and, during elongation, causes transcriptional arrest that activates DNA repair, thus occasionally causing erro...

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Detalles Bibliográficos
Autores principales: Kim, Nayun, Kage, Karen, Matsuda, Fumihiko, Lefranc, Marie-Paule, Storb, Ursula
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198998/
https://www.ncbi.nlm.nih.gov/pubmed/9236193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198998/
https://www.ncbi.nlm.nih.gov/pubmed/9236193

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