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Clinical and Serologic Manifestations of Autoimmune Disease in MRL-lpr/lpr Mice Lacking Nitric Oxide Synthase Type 2
Nitric oxide (NO) is an important mediator of the inflammatory response. MRL–lpr/lpr mice overexpress inducible nitric oxide synthase (NOS2) and overproduce NO in parallel with the development of an autoimmune syndrome with a variety of inflammatory manifestations. In previous studies, we showed tha...
Autores principales: | Gilkeson, Gary S., Mudgett, John S., Seldin, Michael F., Ruiz, Phil, Alexander, Audrey A., Misukonis, Mary A., Pisetsky, David S., Weinberg, J. Brice |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1997
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199001/ https://www.ncbi.nlm.nih.gov/pubmed/9236188 |
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