Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

Ku is a complex of two proteins, Ku70 and Ku80, and functions as a heterodimer to bind DNA double-strand breaks (DSB) and activate DNA-dependent protein kinase. The role of the Ku70 subunit in DNA DSB repair, hypersensitivity to ionizing radiation, and V(D)J recombination was examined in mice that l...

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Detalles Bibliográficos
Autores principales: Ouyang, Honghai, Nussenzweig, Andre, Kurimasa, Akihiro, Soares, Vera da Costa, Li, Xiaoling, Cordon-Cardo, Carlos, Li, Wen-hui, Cheong, Nge, Nussenzweig, Michel, Iliakis, George, Chen, David J., Li, Gloria C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199057/
https://www.ncbi.nlm.nih.gov/pubmed/9294146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199057/
https://www.ncbi.nlm.nih.gov/pubmed/9294146

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