Cargando…

Granule-mediated Killing: Pathways for Granzyme B–initiated Apoptosis

We report that the serine protease granzyme B (GrB), which is crucial for granule-mediated cell killing, initiates apoptosis in target cells by first maturing caspase-10. In addition, GrB has a limited capacity to mature other caspases and to cause cell death independently of the caspases. Compared...

Descripción completa

Detalles Bibliográficos
Autores principales:	Talanian, Robert V., Yang, XiaoHe, Turbov, Jane, Seth, Prem, Ghayur, Tariq, Casiano, Carlos A., Orth, Kim, Froelich, Christopher J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1997
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199091/ https://www.ncbi.nlm.nih.gov/pubmed/9334372

Ejemplares similares

Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway
por: Vermijlen, David, et al.
Publicado: (2004)

Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells
por: Burgener, Sabrina Sofia, et al.
Publicado: (2021)

Granzymes: a family of lymphocyte granule serine proteases
por: Trapani, Joseph A
Publicado: (2001)

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation
por: Sutton, Vivien R., et al.
Publicado: (2000)

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes
Publicado: (1991)

Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis
por: Metkar, Sunil S., et al.
Publicado: (2003)

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
por: Kurioka, A, et al.
Publicado: (2015)

Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
por: Waterhouse, Nigel J., et al.
Publicado: (2006)

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A
Publicado: (1989)

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor
Publicado: (1993)

Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis
por: Ghayur, Tariq, et al.
Publicado: (1996)

ROS signaling during granzyme B-mediated apoptosis
por: Martinvalet, Denis
Publicado: (2015)

Granzymes A and K differentially potentiate LPS-induced cytokine response
por: Wensink, Annette C, et al.
Publicado: (2016)

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
por: Pardo, Julián, et al.
Publicado: (2004)

A clathrin/dynamin- and mannose-6-phosphate receptor–independent pathway for granzyme B–induced cell death
por: Trapani, Joseph A., et al.
Publicado: (2003)

Mitochondria-dependent and -independent Regulation of Granzyme B–induced Apoptosis
por: MacDonald, Glen, et al.
Publicado: (1999)

NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing
por: Prager, Isabel, et al.
Publicado: (2019)

Granzyme B PET imaging of immune-mediated tumor killing as a tool for understanding immunotherapy response
por: LaSalle, Thomas, et al.
Publicado: (2020)

In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells
por: Simon, Markus M., et al.
Publicado: (1997)

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization
por: Shi, Lianfa, et al.
Publicado: (1997)

Natural killer cells kill extracellular Pseudomonas aeruginosa using contact-dependent release of granzymes B and H
por: Feehan, David D., et al.
Publicado: (2022)

Visualization of Cytolytic T Cell Differentiation and Granule Exocytosis with T Cells from Mice Expressing Active Fluorescent Granzyme B
por: Mouchacca, Pierre, et al.
Publicado: (2013)

Rescue from granzyme B-induced apoptosis by Wee1 kinase
Publicado: (1995)

EGFR-Targeted Granzyme B Expressed in NK Cells Enhances Natural Cytotoxicity and Mediates Specific Killing of Tumor Cells
por: Oberoi, Pranav, et al.
Publicado: (2013)

The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer
por: Chuang, C-H, et al.
Publicado: (2014)

Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status: Implications for Initiation of Autoimmunity
por: Casciola-Rosen, Livia, et al.
Publicado: (1999)

Granzymes—Their Role in Colorectal Cancer
por: Pączek, Sara, et al.
Publicado: (2022)

Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs
por: Pearson, Joel D, et al.
Publicado: (2014)

Activation of the Granzyme Pathway in Children With Severe Respiratory Syncytial Virus Infection
por: Bem, Reinout A, et al.
Publicado: (2008)

In silico prediction of the granzyme B degradome
por: Wee, Lawrence JK, et al.
Publicado: (2011)

Modulation of Inflammation by Extracellular Granzyme A
por: van Daalen, Kim R., et al.
Publicado: (2020)

Intracellular and Extracellular Roles of Granzyme K
por: Bouwman, Annemieke C., et al.
Publicado: (2021)

Granzyme B in Autoimmune Skin Disease
por: Gleave, Anna, et al.
Publicado: (2023)

Erratum to: ‘Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs’
por: Pearson, Jodel D., et al.
Publicado: (2016)

Identification and annotation of bovine granzyme genes reveals a novel granzyme encoded within the trypsin-like locus
por: Yang, Jie, et al.
Publicado: (2018)

Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway
por: Woodsworth, Daniel J., et al.
Publicado: (2017)

CD8(+) Granzyme B(+)–Mediated Tissue Injury vs. CD4(+)IFNγ(+)–Mediated Parasite Killing in Human Cutaneous Leishmaniasis
por: Santos, Claire da Silva, et al.
Publicado: (2013)

Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity
por: Chaves-Pozo, Elena, et al.
Publicado: (2019)

Granzyme A Produced by γ(9)δ(2) T Cells Induces Human Macrophages to Inhibit Growth of an Intracellular Pathogen
por: Spencer, Charles T., et al.
Publicado: (2013)

Granzyme B in Inflammatory Diseases: Apoptosis, Inflammation, Extracellular Matrix Remodeling, Epithelial-to-Mesenchymal Transition and Fibrosis
por: Velotti, Francesca, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7dudl5bsmd142cu74bc6tm7hls