Cargando…
Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy
Ultraviolet A (UVA) irradiation is effectively used to treat patients with atopic dermatitis and other T cell mediated, inflammatory skin diseases. In the present study, successful phototherapy of atopic dermatitis was found to result from UVA radiation-induced apoptosis in skin-infiltrating T helpe...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1997
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199141/ https://www.ncbi.nlm.nih.gov/pubmed/9362536 |
_version_ | 1782148144020062208 |
---|---|
author | Morita, Akimichi Werfel, Thomas Stege, Helger Ahrens, Constanze Karmann, Karin Grewe, Markus Grether-Beck, Susanne Ruzicka, Thomas Kapp, Alexander Klotz, Lars-Oliver Sies, Helmut Krutmann, Jean |
author_facet | Morita, Akimichi Werfel, Thomas Stege, Helger Ahrens, Constanze Karmann, Karin Grewe, Markus Grether-Beck, Susanne Ruzicka, Thomas Kapp, Alexander Klotz, Lars-Oliver Sies, Helmut Krutmann, Jean |
author_sort | Morita, Akimichi |
collection | PubMed |
description | Ultraviolet A (UVA) irradiation is effectively used to treat patients with atopic dermatitis and other T cell mediated, inflammatory skin diseases. In the present study, successful phototherapy of atopic dermatitis was found to result from UVA radiation-induced apoptosis in skin-infiltrating T helper cells, leading to T cell depletion from eczematous skin. In vitro, UVA radiation-induced human T helper cell apoptosis was mediated through the FAS/FAS-ligand system, which was activated in irradiated T cells as a consequence of singlet oxygen generation. These studies demonstrate that singlet oxygen is a potent trigger for the induction of human T cell apoptosis. They also identify singlet oxygen generation as a fundamental mechanism of action operative in phototherapy. |
format | Text |
id | pubmed-2199141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21991412008-04-16 Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy Morita, Akimichi Werfel, Thomas Stege, Helger Ahrens, Constanze Karmann, Karin Grewe, Markus Grether-Beck, Susanne Ruzicka, Thomas Kapp, Alexander Klotz, Lars-Oliver Sies, Helmut Krutmann, Jean J Exp Med Brief Definitive Report Ultraviolet A (UVA) irradiation is effectively used to treat patients with atopic dermatitis and other T cell mediated, inflammatory skin diseases. In the present study, successful phototherapy of atopic dermatitis was found to result from UVA radiation-induced apoptosis in skin-infiltrating T helper cells, leading to T cell depletion from eczematous skin. In vitro, UVA radiation-induced human T helper cell apoptosis was mediated through the FAS/FAS-ligand system, which was activated in irradiated T cells as a consequence of singlet oxygen generation. These studies demonstrate that singlet oxygen is a potent trigger for the induction of human T cell apoptosis. They also identify singlet oxygen generation as a fundamental mechanism of action operative in phototherapy. The Rockefeller University Press 1997-11-17 /pmc/articles/PMC2199141/ /pubmed/9362536 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Definitive Report Morita, Akimichi Werfel, Thomas Stege, Helger Ahrens, Constanze Karmann, Karin Grewe, Markus Grether-Beck, Susanne Ruzicka, Thomas Kapp, Alexander Klotz, Lars-Oliver Sies, Helmut Krutmann, Jean Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy |
title | Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy |
title_full | Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy |
title_fullStr | Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy |
title_full_unstemmed | Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy |
title_short | Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy |
title_sort | evidence that singlet oxygen-induced human t helper cell apoptosis is the basic mechanism of ultraviolet-a radiation phototherapy |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199141/ https://www.ncbi.nlm.nih.gov/pubmed/9362536 |
work_keys_str_mv | AT moritaakimichi evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT werfelthomas evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT stegehelger evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT ahrensconstanze evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT karmannkarin evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT grewemarkus evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT gretherbecksusanne evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT ruzickathomas evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT kappalexander evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT klotzlarsoliver evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT sieshelmut evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy AT krutmannjean evidencethatsingletoxygeninducedhumanthelpercellapoptosisisthebasicmechanismofultravioletaradiationphototherapy |