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Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation

Although growth factor receptors are generally thought to carry out their role in signal transduction at the cell surface, many of these transmembrane proteins translocate to the nucleus after ligand stimulation. Here, we show that the nuclear translocation of fibroblast growth factor receptor (FGFR...

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Detalles Bibliográficos
Autores principales: Reilly, John F., Maher, Pamela A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199207/
https://www.ncbi.nlm.nih.gov/pubmed/11257130
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author Reilly, John F.
Maher, Pamela A.
author_facet Reilly, John F.
Maher, Pamela A.
author_sort Reilly, John F.
collection PubMed
description Although growth factor receptors are generally thought to carry out their role in signal transduction at the cell surface, many of these transmembrane proteins translocate to the nucleus after ligand stimulation. Here, we show that the nuclear translocation of fibroblast growth factor receptor (FGFR)1 occurs via a mechanism distinct from classical nuclear import but dependent on importin β, a component of multiple nuclear import pathways. Furthermore, we show that nuclear FGFR1 induces c-Jun and is involved in the regulation of cell proliferation. These data are the first description of a nuclear import pathway for transmembrane growth factor receptors and elucidate a novel signal transduction pathway from the cell surface to the nucleus.
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spelling pubmed-21992072008-05-01 Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation Reilly, John F. Maher, Pamela A. J Cell Biol Report Although growth factor receptors are generally thought to carry out their role in signal transduction at the cell surface, many of these transmembrane proteins translocate to the nucleus after ligand stimulation. Here, we show that the nuclear translocation of fibroblast growth factor receptor (FGFR)1 occurs via a mechanism distinct from classical nuclear import but dependent on importin β, a component of multiple nuclear import pathways. Furthermore, we show that nuclear FGFR1 induces c-Jun and is involved in the regulation of cell proliferation. These data are the first description of a nuclear import pathway for transmembrane growth factor receptors and elucidate a novel signal transduction pathway from the cell surface to the nucleus. The Rockefeller University Press 2001-03-19 /pmc/articles/PMC2199207/ /pubmed/11257130 Text en © 2001 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Report
Reilly, John F.
Maher, Pamela A.
Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation
title Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation
title_full Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation
title_fullStr Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation
title_full_unstemmed Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation
title_short Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation
title_sort importin β–mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199207/
https://www.ncbi.nlm.nih.gov/pubmed/11257130
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