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A new role for BiP: closing the aqueous translocon pore during protein integration into the ER membrane
In mammalian cells, most membrane proteins are inserted cotranslationally into the ER membrane at sites termed translocons. Although each translocon forms an aqueous pore, the permeability barrier of the membrane is maintained during integration, even when the otherwise tight ribosome–translocon sea...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199230/ https://www.ncbi.nlm.nih.gov/pubmed/11807091 http://dx.doi.org/10.1083/jcb.200110074 |