Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast

Although the budding yeast centromere is extremely short (125 bp) compared to those of other eukaryotes, the kinetochore that assembles on this DNA displays a rich molecular complexity. Here, we describe recent advances in our understanding of kinetochore function in budding yeast and present a mode...

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Detalles Bibliográficos
Autores principales: Cheeseman, Iain M., Drubin, David G., Barnes, Georjana
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Mini-Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199245/
https://www.ncbi.nlm.nih.gov/pubmed/11956223
http://dx.doi.org/10.1083/jcb.200201052
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author Cheeseman, Iain M.
Drubin, David G.
Barnes, Georjana
author_facet Cheeseman, Iain M.
Drubin, David G.
Barnes, Georjana
author_sort Cheeseman, Iain M.
collection PubMed
description Although the budding yeast centromere is extremely short (125 bp) compared to those of other eukaryotes, the kinetochore that assembles on this DNA displays a rich molecular complexity. Here, we describe recent advances in our understanding of kinetochore function in budding yeast and present a model describing the attachment that is formed between spindle microtubules and centromeric DNA. This analysis may provide general principles for kinetochore function and regulation.
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spelling pubmed-21992452008-05-01 Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast Cheeseman, Iain M. Drubin, David G. Barnes, Georjana J Cell Biol Mini-Reviews Although the budding yeast centromere is extremely short (125 bp) compared to those of other eukaryotes, the kinetochore that assembles on this DNA displays a rich molecular complexity. Here, we describe recent advances in our understanding of kinetochore function in budding yeast and present a model describing the attachment that is formed between spindle microtubules and centromeric DNA. This analysis may provide general principles for kinetochore function and regulation. The Rockefeller University Press 2002-04-15 /pmc/articles/PMC2199245/ /pubmed/11956223 http://dx.doi.org/10.1083/jcb.200201052 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Mini-Reviews
Cheeseman, Iain M.
Drubin, David G.
Barnes, Georjana
Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast
title Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast
title_full Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast
title_fullStr Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast
title_full_unstemmed Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast
title_short Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast
title_sort simple centromere, complex kinetochore: linking spindle microtubules and centromeric dna in budding yeast
topic Mini-Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199245/
https://www.ncbi.nlm.nih.gov/pubmed/11956223
http://dx.doi.org/10.1083/jcb.200201052
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AT drubindavidg simplecentromerecomplexkinetochorelinkingspindlemicrotubulesandcentromericdnainbuddingyeast
AT barnesgeorjana simplecentromerecomplexkinetochorelinkingspindlemicrotubulesandcentromericdnainbuddingyeast

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