Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

The low-density lipoprotein receptor–related protein (Lrp)-5 functions as a Wnt coreceptor. Here we show that mice with a targeted disruption of Lrp5 develop a low bone mass phenotype. In vivo and in vitro analyses indicate that this phenotype becomes evident postnatally, and demonstrate that it is...

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Detalles Bibliográficos
Autores principales: Kato, Masaki, Patel, Millan S., Levasseur, Regis, Lobov, Ivan, Chang, Benny H.-J., Glass, Donald A., Hartmann, Christine, Li, Lan, Hwang, Tae-Ho, Brayton, Cory F., Lang, Richard A., Karsenty, Gerard, Chan, Lawrence
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199263/
https://www.ncbi.nlm.nih.gov/pubmed/11956231
http://dx.doi.org/10.1083/jcb.200201089

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