Cargando…

Conflicting Views on Chemical Carcinogenesis Arising from the Design and Evaluation of Rodent Carcinogenicity Studies

Conflicting views have been expressed frequently on assessments of human cancer risk of environmental agents based on animal carcinogenicity data; this is primarily because of uncertainties associated with extrapolations of toxicologic findings from studies in experimental animals to human circumsta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Melnick, Ronald L., Thayer, Kristina A., Bucher, John R.
Formato:	Texto
Lenguaje:	English
Publicado:	National Institute of Environmental Health Sciences 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199296/ https://www.ncbi.nlm.nih.gov/pubmed/18197312 http://dx.doi.org/10.1289/ehp.9989

Ejemplares similares

Carcinogenesis studies in rodents for evaluating risks associated with chemical carcinogens in aquatic food animals.
por: Huff, J, et al.
Publicado: (1991)

Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens.
por: Elcombe, Clifford R, et al.
Publicado: (2002)

Prediction of rodent carcinogenicity for 30 chemicals.
por: Ashby, J
Publicado: (1996)

Predicting chemical carcinogenesis in rodents.
por: Wachsman, J T, et al.
Publicado: (1993)

Declaring chemicals "not carcinogenic to humans" requires validation, not speculation.
por: Melnick, Ronald L, et al.
Publicado: (2003)

A Theoretical Approach to the Preselection of Carcinogens and Chemical Carcinogenesis
por: Frank, David A.
Publicado: (1981)

Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents.
por: Huff, J, et al.
Publicado: (1991)

Cage allocation designs for rodent carcinogenicity experiments.
por: Herzberg, A M, et al.
Publicado: (1992)

Cage allocation designs for rodent carcinogenicity experiments
por: Herzberg, Agnes M., et al.
Publicado: (1991)

Predicting the carcinogenicity of chemicals in humans from rodent bioassay data.
por: Goodman, G, et al.
Publicado: (1991)

Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database.
por: Gold, L S, et al.
Publicado: (1989)

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis
por: Smith, Martyn T., et al.
Publicado: (2015)

Ranking the potential carcinogenic hazards to workers from exposures to chemicals that are tumorigenic in rodents.
por: Gold, L S, et al.
Publicado: (1987)

Naturally Occurring Carcinogens, Mutagens and Modulators of Carcinogenesis
por: Fox, M.
Publicado: (1980)

Mechanisms of multistep carcinogenesis and carcinogen risk assessment.
por: Barrett, J C
Publicado: (1993)

Prediction of the rodent carcinogenicity of organic compounds from their chemical structures using the FALS method.
por: Moriguchi, I, et al.
Publicado: (1996)

Prediction of rodent carcinogenicity of further 30 chemicals bioassayed by the U.S. National Toxicology Program.
por: Benigni, R, et al.
Publicado: (1996)

Developmental Neurotoxicity of Perfluorinated Chemicals Modeled in Vitro
por: Slotkin, Theodore A., et al.
Publicado: (2008)

Miscellaneous Chemical Carcinogens: Chemical Constitution and Carcinogenic Activity
por: Badger, G. M.
Publicado: (1956)

Cell proliferation and chemical carcinogenesis: symposium overview.
por: Melnick, R L, et al.
Publicado: (1993)

Oxidative Stress in the Carcinogenicity of Chemical Carcinogens
por: Kakehashi, Anna, et al.
Publicado: (2013)

Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis.
por: Melnick, R L, et al.
Publicado: (1996)

Predictions for the outcome of rodent carcinogenicity bioassays: identification of trans-species carcinogens and noncarcinogens.
por: Tennant, R W, et al.
Publicado: (1996)

Initiation/promotion versus complete carcinogenicity in the rodent liver
por: Ashby, John, et al.
Publicado: (1983)

Carcinogenic Effect of Wireless Communication Radiation in Rodents
por: Lin, James C.
Publicado: (2009)

Studies on Tricycloquinazoline Carcinogenesis: Interaction of Carcinogen with Skin Components
por: Baldwin, R. W., et al.
Publicado: (1962)

Retardation of Azo-Carcinogenesis by Non-Carcinogenic Azo-Compounds
por: Crabtree, H. G.
Publicado: (1955)

Role of RNA modifications in carcinogenesis and carcinogen damage response
por: Verghese, Michelle, et al.
Publicado: (2022)

A mechanism-mediated model for carcinogenicity: model content and prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 25 organic chemicals.
por: Purdy, R
Publicado: (1996)

The Carcinogenic Hydrocarbons: Chemical Constitution and Carcinogenic Activity
por: Badger, G. M.
Publicado: (1948)

Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: nongenotoxic carcinogens and genotoxic noncarcinogens.
por: Yoshikawa, K
Publicado: (1996)

Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies
por: Greim, Helmut, et al.
Publicado: (2015)

A retrospective evaluation of COMPACT predictions of the outcome of NTP rodent carcinogenicity testing.
por: Lewis, D F, et al.
Publicado: (1995)

Anticonvulsant effects of cenobamate in chemically and electrically induced seizure models in rodents
por: Melnick, Susan M., et al.
Publicado: (2023)

Carcinogenic Chemical Agents
por: Cook, J. W.
Publicado: (1938)

Insulin Glargine: A Reevaluation of Rodent Carcinogenicity Findings
por: Stammberger, Ingo, et al.
Publicado: (2012)

Oncogene activation in experimental carcinogenesis: the role of carcinogen and tissue specificity.
por: Garte, S J, et al.
Publicado: (1989)

The Carcinogenic Azo- Compounds: Chemical Constitution and Carcinogenic Activity
por: Badger, G. M., et al.
Publicado: (1952)

Carcinogenicity of 1,3-butadiene.
por: Melnick, R L, et al.
Publicado: (1993)

Role of Environmental Chemicals in Diabetes and Obesity: A National Toxicology Program Workshop Review
por: Thayer, Kristina A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_tdd70nl4sbeeh82213qbb2qgio