Cargando…

TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal

Developmental sympathetic neuron death is determined by functional interactions between the TrkA/NGF receptor and the p75 neurotrophin receptor (p75NTR). A key question is whether p75NTR promotes apoptosis by directly inhibiting or modulating TrkA activity, or by stimulating cell death independently...

Descripción completa

Detalles Bibliográficos
Autores principales:	Majdan, Marta, Walsh, Gregory S., Aloyz, Raquel, Miller, Freda D.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2001
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199335/ https://www.ncbi.nlm.nih.gov/pubmed/11756477 http://dx.doi.org/10.1083/jcb.200110017

Ejemplares similares

P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors
por: Aloyz, Raquel S., et al.
Publicado: (1998)

The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death
por: Bamji, Shernaz X., et al.
Publicado: (1998)

Molecular Mechanism of Switching of TrkA/p75(NTR) Signaling in Monocrotophos Induced Neurotoxicity
por: Kumar, Vivek, et al.
Publicado: (2015)

Expression of NGF/proNGF and Their Receptors TrkA, p75(NTR) and Sortilin in Melanoma
por: Marsland, Mark, et al.
Publicado: (2022)

Characterization of NGF, trkA(NGFR), and p75(NTR) in Retina of Mice Lacking Reelin Glycoprotein
por: Balzamino, Bijorn Omar, et al.
Publicado: (2014)

QS8: The Roles of the TrkA and p75NTR NGF Receptors in Corneal Wound Healing
por: Tajdaran, Kiana, et al.
Publicado: (2021)

Expression of Nerve Growth Factor (NGF), TrkA, and p75(NTR) in Developing Human Fetal Teeth
por: Mitsiadis, Thimios A., et al.
Publicado: (2016)

Author Correction: Molecular Mechanism of Switching of TrkA/p75(NTR) Signaling in Monocrotophos Induced Neurotoxicity
por: Kumar, Vivek, et al.
Publicado: (2020)

Effects of pre- and postnatal deletion of the transcription factor NKx2-1 on the expression of NGF, trkA, trkB and p75NTR in mice
por: Ersözlü, S, et al.
Publicado: (2015)

Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats
por: Fortress, Ashley M., et al.
Publicado: (2011)

Spatio-temporal expression profile of NGF and the two-receptor system, TrkA and p75NTR, in experimental autoimmune encephalomyelitis
por: Delivanoglou, Nickoleta, et al.
Publicado: (2020)

TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition
por: Franco, María Luisa, et al.
Publicado: (2021)

Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function
por: Connor, Blaine, et al.
Publicado: (2023)

Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75(NTR) Signal Pathway
por: Zhang, Fan, et al.
Publicado: (2021)

TrkA Co-Receptors: The Janus Face of TrkA?
por: Trouvilliez, Sarah, et al.
Publicado: (2023)

NGF Modulates trkA(NGFR)/p75(NTR) in αSMA-Expressing Conjunctival Fibroblasts from Human Ocular Cicatricial Pemphigoid (OCP)
por: Micera, Alessandra, et al.
Publicado: (2015)

NGF and Neurotrophin-3 Both Activate TrkA on Sympathetic Neurons but Differentially Regulate Survival and Neuritogenesis
por: Belliveau, Daniel J., et al.
Publicado: (1997)

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
por: Mason, Ashley J., et al.
Publicado: (2023)

Interaction between the transmembrane domains of neurotrophin receptors p75 and TrkA mediates their reciprocal activation
por: Franco, María L., et al.
Publicado: (2021)

(−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75(NTR) Signaling in APP/PS1 Transgenic Mice
por: Liu, Mingyan, et al.
Publicado: (2013)

SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
por: Marsh, H. Nicholas, et al.
Publicado: (2003)

Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors
por: Toni, T, et al.
Publicado: (2014)

NGF signaling in PC12 cells: the cooperation of p75(NTR) with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade
por: Negrini, Sara, et al.
Publicado: (2013)

Selective Activation of Striatal NGF-TrkA/p75NTR/MAPK Intracellular Signaling in Rats That Show Suppression of Methamphetamine Intake 30 Days following Drug Abstinence
por: Torres, Oscar V, et al.
Publicado: (2017)

Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75(NTR)
por: Kropf, Erika, et al.
Publicado: (2023)

The neurotrophin receptor, gp75, forms a complex with the receptor tyrosine kinase TrkA
Publicado: (1996)

High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair
por: Conroy, Jacinta N., et al.
Publicado: (2022)

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
por: Ye, Mengchen, et al.
Publicado: (2018)

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation
por: Josephy-Hernandez, Sylvia, et al.
Publicado: (2019)

NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
por: Ruggeri, P, et al.
Publicado: (2016)

Rapid Retrograde Tyrosine Phosphorylation of trkA and Other Proteins in Rat Sympathetic Neurons in Compartmented Cultures
por: Senger, Donna L., et al.
Publicado: (1997)

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria
por: Feinberg, Konstantin, et al.
Publicado: (2017)

Divergent Roles of p75(NTR) and Trk Receptors in BDNF's Effects on Dendritic Spine Density and Morphology
por: Chapleau, Christopher A., et al.
Publicado: (2012)

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies
por: Brito, V, et al.
Publicado: (2013)

NGF – the TrkA to successful pain treatment
por: Kumar, Vinayak, et al.
Publicado: (2012)

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents
por: Canu, Nadia, et al.
Publicado: (2017)

Structural Characterization of the Self-Association of the Death Domain of p75(NTR)
por: Qu, Qianhui, et al.
Publicado: (2013)

Involvement of TrkB- and p75(NTR)-signaling pathways in two contrasting forms of long-lasting synaptic plasticity
por: Sakuragi, Shigeo, et al.
Publicado: (2013)

Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors
por: Brahimi, Fouad, et al.
Publicado: (2014)

Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro‐cardiac junction
por: Dokshokova, Lolita, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_20uofpu6gkr273hqlmuncrugck