Caveolae/raft-dependent endocytosis

Although caveolae are well-characterized subdomains of glycolipid rafts, their distinctive morphology and association with caveolins has led to their internalization being considered different from that of rafts. In this review, we propose that caveolae and rafts are internalized via a common pathwa...

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Detalles Bibliográficos
Autores principales: Nabi, Ivan R., Le, Phuong U.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199359/
https://www.ncbi.nlm.nih.gov/pubmed/12771123
http://dx.doi.org/10.1083/jcb.200302028
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author Nabi, Ivan R.
Le, Phuong U.
author_facet Nabi, Ivan R.
Le, Phuong U.
author_sort Nabi, Ivan R.
collection PubMed
description Although caveolae are well-characterized subdomains of glycolipid rafts, their distinctive morphology and association with caveolins has led to their internalization being considered different from that of rafts. In this review, we propose that caveolae and rafts are internalized via a common pathway, caveolae/raft-dependent endocytosis, defined by its clathrin independence, dynamin dependence, and sensitivity to cholesterol depletion. The regulatory role of caveolin-1 and ligand sorting in this complex endocytic pathway are specifically addressed.
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spelling pubmed-21993592008-05-01 Caveolae/raft-dependent endocytosis Nabi, Ivan R. Le, Phuong U. J Cell Biol Mini-Review Although caveolae are well-characterized subdomains of glycolipid rafts, their distinctive morphology and association with caveolins has led to their internalization being considered different from that of rafts. In this review, we propose that caveolae and rafts are internalized via a common pathway, caveolae/raft-dependent endocytosis, defined by its clathrin independence, dynamin dependence, and sensitivity to cholesterol depletion. The regulatory role of caveolin-1 and ligand sorting in this complex endocytic pathway are specifically addressed. The Rockefeller University Press 2003-05-26 /pmc/articles/PMC2199359/ /pubmed/12771123 http://dx.doi.org/10.1083/jcb.200302028 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Mini-Review
Nabi, Ivan R.
Le, Phuong U.
Caveolae/raft-dependent endocytosis
title Caveolae/raft-dependent endocytosis
title_full Caveolae/raft-dependent endocytosis
title_fullStr Caveolae/raft-dependent endocytosis
title_full_unstemmed Caveolae/raft-dependent endocytosis
title_short Caveolae/raft-dependent endocytosis
title_sort caveolae/raft-dependent endocytosis
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199359/
https://www.ncbi.nlm.nih.gov/pubmed/12771123
http://dx.doi.org/10.1083/jcb.200302028
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