Mutations in the Essential Spindle Checkpoint Gene bub1 Cause Chromosome Missegregation and Fail to Block Apoptosis in Drosophila

We have characterized the Drosophila mitotic checkpoint control protein Bub1 and obtained mutations in the bub1 gene. Drosophila Bub1 localizes strongly to the centromere/kinetochore of mitotic and meiotic chromosomes that have not yet reached the metaphase plate. Animals homozygous for P-element–in...

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Detalles Bibliográficos
Autores principales: Basu, Joydeep, Bousbaa, Hassan, Logarinho, Elsa, Li, ZeXiao, Williams, Byron C., Lopes, Carla, Sunkel, Claudio E., Goldberg, Michael L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199734/
https://www.ncbi.nlm.nih.gov/pubmed/10402457

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