HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte

By immunocytochemistry and in situ hybridization at the electron microscopy level, and by the PCR technique, we have shown that HIV-1 binds and enters normal sperm; that viral particles, their antigens, and nucleic acid are present in sperm from HIV-1 infected men; and that such sperm can transfer H...

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Detalles Bibliográficos
Autores principales: Baccetti, B, Benedetto, A, Burrini, AG, Collodel, G, Ceccarini, EC, Crisa, N, Di Caro, A, Estenoz, M, Garbuglia, AR, Massacesi, A, Piomboni, P, Renieri, T, Solazzo, D
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1994
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200050/
https://www.ncbi.nlm.nih.gov/pubmed/7962075
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author Baccetti, B
Benedetto, A
Burrini, AG
Collodel, G
Ceccarini, EC
Crisa, N
Di Caro, A
Estenoz, M
Garbuglia, AR
Massacesi, A
Piomboni, P
Renieri, T
Solazzo, D
author_facet Baccetti, B
Benedetto, A
Burrini, AG
Collodel, G
Ceccarini, EC
Crisa, N
Di Caro, A
Estenoz, M
Garbuglia, AR
Massacesi, A
Piomboni, P
Renieri, T
Solazzo, D
author_sort Baccetti, B
collection PubMed
description By immunocytochemistry and in situ hybridization at the electron microscopy level, and by the PCR technique, we have shown that HIV-1 binds and enters normal sperm; that viral particles, their antigens, and nucleic acid are present in sperm from HIV-1 infected men; and that such sperm can transfer HIV-1 like particles to normal human oocytes. We also present evidence that a galactosylceramide-like compound is present on the sperm membrane and could function as an alternative receptor for HIV.
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spelling pubmed-22000502008-05-01 HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte Baccetti, B Benedetto, A Burrini, AG Collodel, G Ceccarini, EC Crisa, N Di Caro, A Estenoz, M Garbuglia, AR Massacesi, A Piomboni, P Renieri, T Solazzo, D J Cell Biol Articles By immunocytochemistry and in situ hybridization at the electron microscopy level, and by the PCR technique, we have shown that HIV-1 binds and enters normal sperm; that viral particles, their antigens, and nucleic acid are present in sperm from HIV-1 infected men; and that such sperm can transfer HIV-1 like particles to normal human oocytes. We also present evidence that a galactosylceramide-like compound is present on the sperm membrane and could function as an alternative receptor for HIV. The Rockefeller University Press 1994-11-02 /pmc/articles/PMC2200050/ /pubmed/7962075 Text en Copyright © 1994, This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Baccetti, B
Benedetto, A
Burrini, AG
Collodel, G
Ceccarini, EC
Crisa, N
Di Caro, A
Estenoz, M
Garbuglia, AR
Massacesi, A
Piomboni, P
Renieri, T
Solazzo, D
HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte
title HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte
title_full HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte
title_fullStr HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte
title_full_unstemmed HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte
title_short HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte
title_sort hiv-particles in spermatozoa of patients with aids and their transfer into the oocyte
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200050/
https://www.ncbi.nlm.nih.gov/pubmed/7962075
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