CYTOCHALASIN-B: TIME-LAPSE CINEMATOGRAPHIC STUDIES ON ITS EFFECTS ON CYTOKINESIS

L cells exposed to cytochalasin-B (cyto-B) show the normal development of deep cleavage furrows in both bipolar and multipolar cell divisions Due to the drug-induced inhibition of cellular motility, the resulting daughter cells do not move away from each other but reunite to form multinucleate cells...

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Detalles Bibliográficos
Autor principal: Krishan, Awtar
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200289/
https://www.ncbi.nlm.nih.gov/pubmed/5044763
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author Krishan, Awtar
author_facet Krishan, Awtar
author_sort Krishan, Awtar
collection PubMed
description L cells exposed to cytochalasin-B (cyto-B) show the normal development of deep cleavage furrows in both bipolar and multipolar cell divisions Due to the drug-induced inhibition of cellular motility, the resulting daughter cells do not move away from each other but reunite to form multinucleate cells. In mitotic cells from cultures exposed to cyto-B for long periods of time, vigorous blebbing and contraction of the cell surface is seen The evidence from time-lapse studies presented suggests that cyto-B-induced multinucleate cells are formed, not by the failure of the cleavage furrow, but by the drug-induced changes in surface activity and motility of cells after division.
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spelling pubmed-22002892008-05-01 CYTOCHALASIN-B: TIME-LAPSE CINEMATOGRAPHIC STUDIES ON ITS EFFECTS ON CYTOKINESIS Krishan, Awtar J Cell Biol Article L cells exposed to cytochalasin-B (cyto-B) show the normal development of deep cleavage furrows in both bipolar and multipolar cell divisions Due to the drug-induced inhibition of cellular motility, the resulting daughter cells do not move away from each other but reunite to form multinucleate cells. In mitotic cells from cultures exposed to cyto-B for long periods of time, vigorous blebbing and contraction of the cell surface is seen The evidence from time-lapse studies presented suggests that cyto-B-induced multinucleate cells are formed, not by the failure of the cleavage furrow, but by the drug-induced changes in surface activity and motility of cells after division. The Rockefeller University Press 1972-09-01 /pmc/articles/PMC2200289/ /pubmed/5044763 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Krishan, Awtar
CYTOCHALASIN-B: TIME-LAPSE CINEMATOGRAPHIC STUDIES ON ITS EFFECTS ON CYTOKINESIS
title CYTOCHALASIN-B: TIME-LAPSE CINEMATOGRAPHIC STUDIES ON ITS EFFECTS ON CYTOKINESIS
title_full CYTOCHALASIN-B: TIME-LAPSE CINEMATOGRAPHIC STUDIES ON ITS EFFECTS ON CYTOKINESIS
title_fullStr CYTOCHALASIN-B: TIME-LAPSE CINEMATOGRAPHIC STUDIES ON ITS EFFECTS ON CYTOKINESIS
title_full_unstemmed CYTOCHALASIN-B: TIME-LAPSE CINEMATOGRAPHIC STUDIES ON ITS EFFECTS ON CYTOKINESIS
title_short CYTOCHALASIN-B: TIME-LAPSE CINEMATOGRAPHIC STUDIES ON ITS EFFECTS ON CYTOKINESIS
title_sort cytochalasin-b: time-lapse cinematographic studies on its effects on cytokinesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200289/
https://www.ncbi.nlm.nih.gov/pubmed/5044763
work_keys_str_mv AT krishanawtar cytochalasinbtimelapsecinematographicstudiesonitseffectsoncytokinesis

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