Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction

A simple and single-step synthesis of 2- and 3-acyl substituted benzothiophenes has been described via environmentally benign acylation of benzothiophene with in situ generated acyl trifluoroacetates. Both aliphatic and aromatic carboxylic acids participated in trifluoroacetic anhydride/phosphoric a...

Descripción completa

Detalles Bibliográficos
Autores principales: Pal, Sarbani, Khan, Mohammad Ashrafuddin, Bindu, P, Dubey, P K
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2007
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200667/
https://www.ncbi.nlm.nih.gov/pubmed/17961232
http://dx.doi.org/10.1186/1860-5397-3-35
_version_ 1782148296817508352
author Pal, Sarbani
Khan, Mohammad Ashrafuddin
Bindu, P
Dubey, P K
author_facet Pal, Sarbani
Khan, Mohammad Ashrafuddin
Bindu, P
Dubey, P K
author_sort Pal, Sarbani
collection PubMed
description A simple and single-step synthesis of 2- and 3-acyl substituted benzothiophenes has been described via environmentally benign acylation of benzothiophene with in situ generated acyl trifluoroacetates. Both aliphatic and aromatic carboxylic acids participated in trifluoroacetic anhydride/phosphoric acid mediated C-C bond forming reactions under solvent-free conditions affording acyl benzothiophenes in good overall yields.
format Text
id pubmed-2200667
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-22006672008-01-16 Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction Pal, Sarbani Khan, Mohammad Ashrafuddin Bindu, P Dubey, P K Beilstein J Org Chem Preliminary Communication A simple and single-step synthesis of 2- and 3-acyl substituted benzothiophenes has been described via environmentally benign acylation of benzothiophene with in situ generated acyl trifluoroacetates. Both aliphatic and aromatic carboxylic acids participated in trifluoroacetic anhydride/phosphoric acid mediated C-C bond forming reactions under solvent-free conditions affording acyl benzothiophenes in good overall yields. Beilstein-Institut 2007-10-25 /pmc/articles/PMC2200667/ /pubmed/17961232 http://dx.doi.org/10.1186/1860-5397-3-35 Text en Copyright © 2007, Pal et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Preliminary Communication
Pal, Sarbani
Khan, Mohammad Ashrafuddin
Bindu, P
Dubey, P K
Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction
title Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction
title_full Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction
title_fullStr Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction
title_full_unstemmed Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction
title_short Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction
title_sort transition-metal/lewis acid free synthesis of acyl benzothiophenes via c-c bond forming reaction
topic Preliminary Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200667/
https://www.ncbi.nlm.nih.gov/pubmed/17961232
http://dx.doi.org/10.1186/1860-5397-3-35
work_keys_str_mv AT palsarbani transitionmetallewisacidfreesynthesisofacylbenzothiophenesviaccbondformingreaction
AT khanmohammadashrafuddin transitionmetallewisacidfreesynthesisofacylbenzothiophenesviaccbondformingreaction
AT bindup transitionmetallewisacidfreesynthesisofacylbenzothiophenesviaccbondformingreaction
AT dubeypk transitionmetallewisacidfreesynthesisofacylbenzothiophenesviaccbondformingreaction

Ejemplares similares