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Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells

BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) overexpression has been linked to tumor progression and poor prognosis. We investigated whether targeting of HIF-1 using chetomin, a disrupter of the interaction of HIF-1 with the transcriptional coactivator p300, influences the radiosensitivity of hypo...

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Detalles Bibliográficos
Autores principales:	Staab, Adrian, Loeffler, Jürgen, Said, Harun M, Diehlmann, Désirée, Katzer, Astrid, Beyer, Melanie, Fleischer, Markus, Schwab, Franz, Baier, Kurt, Einsele, Hermann, Flentje, Michael, Vordermark, Dirk
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200672/ https://www.ncbi.nlm.nih.gov/pubmed/17999771 http://dx.doi.org/10.1186/1471-2407-7-213

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