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Effects of Lithium on Different Membrane Components of Crayfish Stretch Receptor Neurons
Unlike several other varieties of input membrane, that of the crayfish stretch receptor develops a generator potential in response to stretch when all the Na of the medium is replaced with Li. However, Li depolarizes the receptor neuron, the soma membrane becoming more depolarized than that of the a...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1968
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2201213/ https://www.ncbi.nlm.nih.gov/pubmed/5654404 |
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author | Obara, Shosaku Grundfest, Harry |
author_facet | Obara, Shosaku Grundfest, Harry |
author_sort | Obara, Shosaku |
collection | PubMed |
description | Unlike several other varieties of input membrane, that of the crayfish stretch receptor develops a generator potential in response to stretch when all the Na of the medium is replaced with Li. However, Li depolarizes the receptor neuron, the soma membrane becoming more depolarized than that of the axon. During exposure to Li the cell usually fires spontaneously for a period, and when it becomes quiescent spike electrogenesis fails in the soma but persists in the axon. These effects are seen in the rapidly adapting as well as the slowly adapting cells. The block of spike electrogenesis of the soma membrane is only partly due to the Li-induced depolarization and a significant role must be ascribed to a specific effect of Li. |
format | Text |
id | pubmed-2201213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1968 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22012132008-04-23 Effects of Lithium on Different Membrane Components of Crayfish Stretch Receptor Neurons Obara, Shosaku Grundfest, Harry J Gen Physiol Article Unlike several other varieties of input membrane, that of the crayfish stretch receptor develops a generator potential in response to stretch when all the Na of the medium is replaced with Li. However, Li depolarizes the receptor neuron, the soma membrane becoming more depolarized than that of the axon. During exposure to Li the cell usually fires spontaneously for a period, and when it becomes quiescent spike electrogenesis fails in the soma but persists in the axon. These effects are seen in the rapidly adapting as well as the slowly adapting cells. The block of spike electrogenesis of the soma membrane is only partly due to the Li-induced depolarization and a significant role must be ascribed to a specific effect of Li. The Rockefeller University Press 1968-05-01 /pmc/articles/PMC2201213/ /pubmed/5654404 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Obara, Shosaku Grundfest, Harry Effects of Lithium on Different Membrane Components of Crayfish Stretch Receptor Neurons |
title | Effects of Lithium on Different Membrane Components of Crayfish Stretch Receptor Neurons |
title_full | Effects of Lithium on Different Membrane Components of Crayfish Stretch Receptor Neurons |
title_fullStr | Effects of Lithium on Different Membrane Components of Crayfish Stretch Receptor Neurons |
title_full_unstemmed | Effects of Lithium on Different Membrane Components of Crayfish Stretch Receptor Neurons |
title_short | Effects of Lithium on Different Membrane Components of Crayfish Stretch Receptor Neurons |
title_sort | effects of lithium on different membrane components of crayfish stretch receptor neurons |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2201213/ https://www.ncbi.nlm.nih.gov/pubmed/5654404 |
work_keys_str_mv | AT obarashosaku effectsoflithiumondifferentmembranecomponentsofcrayfishstretchreceptorneurons AT grundfestharry effectsoflithiumondifferentmembranecomponentsofcrayfishstretchreceptorneurons |